癌症中的Ephrin受体A2型(EphA2)靶向治疗:专利回顾(2018年至今)。

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL Expert Opinion on Therapeutic Patents Pub Date : 2024-09-11 DOI:10.1080/13543776.2024.2402382
Massimiliano Tognolini,Francesca Romana Ferrari,Alfonso Zappia,Carmine Giorgio
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引用次数: 0

摘要

导言EphA2是一种酪氨酸激酶受体,被认为是一种很有前景的癌症靶点。针对 EphA2 受体采用了不同的方法,大量临床前数据证明了该受体在临床肿瘤学诊断和癌症治疗(包括免疫疗法)中的潜在利用价值。 涵盖领域在本综述中,我们总结了近期涉及癌症中 EphA2 靶向的专利。为此,我们使用了专利数据库 Patentscope,时间跨度为 2018 年至今。在同行评审期刊上发表的发明的临床前和临床数据也在考虑之列。此外,如果有临床试验(clinicalTrial.gov)标识符(NCT 编号),我们也将其纳入其中。为了更方便、更直接地阅读,我们根据在临床肿瘤学中利用 EphA2 的发明的性质(aptamers、小分子、抗体、肽、抗原和嵌合抗原受体),将专利分为不同类别。不过,这些知识产权(其中一些有强有力的临床前证据支持)让我们看到了希望:在发现 EphA2 30 多年后,我们终于能看到首个 EphA2 靶向药物获批用于临床肿瘤学。
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Ephrin receptor type-A2 (EphA2) targeting in cancer: a patent review (2018-present).
INTRODUCTION EphA2 is a tyrosine kinase receptor and is considered a promising target in cancer. Different approaches are used to target EphA2 receptor, and a lot of preclinical data demonstrate the potential exploitation of this receptor in clinical oncology for diagnosis and cancer therapy, including immunotherapy. AREAS COVERED In this review, we have summarized the recent patents involving the EphA2 targeting in cancer. For this aim, we used the patent database Patentscope covering the time period of 2018-present. Preclinical and clinical data of the inventions were considered when published on peer reviewed journals. Moreover, the clinicalTrial.gov identifiers (NCT numbers) were included when available. For an easier and more immediate reading, we classify the patents in different categories, considering the nature (aptamers, small molecules, antibodies, peptides, antigens and chimeric antigen receptors) of the inventions exploiting EphA2 in clinical oncology. EXPERT OPINION Despite the availability of a plethora of chemically diverse agents, there are no approved anticancer drugs targeting EphA2 yet. However, these intellectual properties, some of which supported by strong preclinical evidence, keep the hope that, after more than 30 years from its discovery, we will finally see the first EphA2 targeting agent approved in clinical oncology.
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来源期刊
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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