Yang Li, Xiaoyan Liu, Zhongming Liu, Shoujuan Wang, Fangong Kong
{"title":"用于高效装载和持续释放药物的纳米纤维素复合气凝胶","authors":"Yang Li, Xiaoyan Liu, Zhongming Liu, Shoujuan Wang, Fangong Kong","doi":"10.1007/s10570-024-06061-x","DOIUrl":null,"url":null,"abstract":"<p>The development of effective drug delivery systems is crucial for improving the efficacy of cancer drugs, in order to overcome the issues of low drug loading and drug burst release. Nanocellulose composite aerogel was prepared as a drug carrier for 5-fluorouracil, which had the advantages of three-dimensional network structures, high porosity and good biocompatibility, and its loading capacity was much higher than that of other bio-based drug carriers. Fourier-transform infrared, scanning electron microscopy, X-ray photoelectron spectroscopy, cytotoxicity analysis, and other analytical techniques were used to analyse the physical and chemical structures of nanocellulose composite aerogels. The analysis revealed that the introduction of β-cyclodextrin and sodium hyaluronate led to good compressibility, rich network structure, and abundant adsorption active sites of the nanocellulose composite aerogel, which was more suitable as a drug carrier. The maximum amount of 5-fluorouracil on the nanocellulose composite aerogel through coating and hydrogen bonding reached 486.93 mg/g. The drug release curves of the nanocellulose composite aerogels depended on pH and conformed to the first-order kinetic model and Korsmeyer-Peppas model. Nanocellulose composite aerogels exhibited a high loading capacity and controllable release of 5-fluorouracil, with great potential for biomedical applications.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":511,"journal":{"name":"Cellulose","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanocellulose composite aerogels for efficient drug loading and sustained release\",\"authors\":\"Yang Li, Xiaoyan Liu, Zhongming Liu, Shoujuan Wang, Fangong Kong\",\"doi\":\"10.1007/s10570-024-06061-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The development of effective drug delivery systems is crucial for improving the efficacy of cancer drugs, in order to overcome the issues of low drug loading and drug burst release. Nanocellulose composite aerogel was prepared as a drug carrier for 5-fluorouracil, which had the advantages of three-dimensional network structures, high porosity and good biocompatibility, and its loading capacity was much higher than that of other bio-based drug carriers. Fourier-transform infrared, scanning electron microscopy, X-ray photoelectron spectroscopy, cytotoxicity analysis, and other analytical techniques were used to analyse the physical and chemical structures of nanocellulose composite aerogels. The analysis revealed that the introduction of β-cyclodextrin and sodium hyaluronate led to good compressibility, rich network structure, and abundant adsorption active sites of the nanocellulose composite aerogel, which was more suitable as a drug carrier. The maximum amount of 5-fluorouracil on the nanocellulose composite aerogel through coating and hydrogen bonding reached 486.93 mg/g. The drug release curves of the nanocellulose composite aerogels depended on pH and conformed to the first-order kinetic model and Korsmeyer-Peppas model. Nanocellulose composite aerogels exhibited a high loading capacity and controllable release of 5-fluorouracil, with great potential for biomedical applications.</p><h3 data-test=\\\"abstract-sub-heading\\\">Graphical abstract</h3>\",\"PeriodicalId\":511,\"journal\":{\"name\":\"Cellulose\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cellulose\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1007/s10570-024-06061-x\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, PAPER & WOOD\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellulose","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s10570-024-06061-x","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, PAPER & WOOD","Score":null,"Total":0}
Nanocellulose composite aerogels for efficient drug loading and sustained release
The development of effective drug delivery systems is crucial for improving the efficacy of cancer drugs, in order to overcome the issues of low drug loading and drug burst release. Nanocellulose composite aerogel was prepared as a drug carrier for 5-fluorouracil, which had the advantages of three-dimensional network structures, high porosity and good biocompatibility, and its loading capacity was much higher than that of other bio-based drug carriers. Fourier-transform infrared, scanning electron microscopy, X-ray photoelectron spectroscopy, cytotoxicity analysis, and other analytical techniques were used to analyse the physical and chemical structures of nanocellulose composite aerogels. The analysis revealed that the introduction of β-cyclodextrin and sodium hyaluronate led to good compressibility, rich network structure, and abundant adsorption active sites of the nanocellulose composite aerogel, which was more suitable as a drug carrier. The maximum amount of 5-fluorouracil on the nanocellulose composite aerogel through coating and hydrogen bonding reached 486.93 mg/g. The drug release curves of the nanocellulose composite aerogels depended on pH and conformed to the first-order kinetic model and Korsmeyer-Peppas model. Nanocellulose composite aerogels exhibited a high loading capacity and controllable release of 5-fluorouracil, with great potential for biomedical applications.
期刊介绍:
Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.