P.N. d’Ailly, O.J.M. Schäffers, C. Deugd, M.A. Versnel, H.J.G. van de Werken, E.M.J. Bindels, S.W. Tas, J. Gribnau, N.W.L. Schep, R.J. Bisoendial
{"title":"用于预测类风湿关节炎生物治疗反应的滑膜转录组分析：可行性研究","authors":"P.N. d’Ailly, O.J.M. Schäffers, C. Deugd, M.A. Versnel, H.J.G. van de Werken, E.M.J. Bindels, S.W. Tas, J. Gribnau, N.W.L. Schep, R.J. Bisoendial","doi":"10.1101/2024.08.28.24312608","DOIUrl":null,"url":null,"abstract":"<strong>Introduction</strong> Disease-Modifying Anti-Rheumatic Drug (DMARD) treatment fails to achieve clinical remission in a substantial proportion of patients with rheumatoid arthritis (RA). Patient-derived synovial tissue (ST)-signatures, thought to determine this heterogeneity of treatment responses, can be studied by single-cell RNA sequencing (scRNA-seq).","PeriodicalId":501212,"journal":{"name":"medRxiv - Rheumatology","volume":"18 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synovial Transcriptome Profiling for Predicting Biological Treatment Response in Rheumatoid Arthritis: A Feasibility study\",\"authors\":\"P.N. d’Ailly, O.J.M. Schäffers, C. Deugd, M.A. Versnel, H.J.G. van de Werken, E.M.J. Bindels, S.W. Tas, J. Gribnau, N.W.L. Schep, R.J. Bisoendial\",\"doi\":\"10.1101/2024.08.28.24312608\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Introduction</strong> Disease-Modifying Anti-Rheumatic Drug (DMARD) treatment fails to achieve clinical remission in a substantial proportion of patients with rheumatoid arthritis (RA). Patient-derived synovial tissue (ST)-signatures, thought to determine this heterogeneity of treatment responses, can be studied by single-cell RNA sequencing (scRNA-seq).\",\"PeriodicalId\":501212,\"journal\":{\"name\":\"medRxiv - Rheumatology\",\"volume\":\"18 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Rheumatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.08.28.24312608\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.28.24312608","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synovial Transcriptome Profiling for Predicting Biological Treatment Response in Rheumatoid Arthritis: A Feasibility study
Introduction Disease-Modifying Anti-Rheumatic Drug (DMARD) treatment fails to achieve clinical remission in a substantial proportion of patients with rheumatoid arthritis (RA). Patient-derived synovial tissue (ST)-signatures, thought to determine this heterogeneity of treatment responses, can be studied by single-cell RNA sequencing (scRNA-seq).
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