成对的 C 型凝集素受体介导了秀丽隐杆线虫对不同卵菌病原体的特异性识别。

Kenneth Liu, Manish Grover, Franziska Trusch, Christina Vagena-Pantoula, Domenica Ippolito, Michalis Barkoulas
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引用次数: 0

摘要

宿主受体通常存在于免疫细胞表面,通过检测病原体或损害相关分子模式,可启动先天性免疫反应。虽然某些无脊椎动物(如草履虫)缺乏专业的免疫细胞,但它们仍会以病原体特异性的方式对感染做出反应。对于典型病原体识别受体的同源物是否也在线虫中发挥作用,多年来一直存在争议。在这里,我们发现 C 型凝集素受体介导了线虫对不同卵菌的物种特异性识别。CLEC-27/CLEC-35对识别腐霉菌Myzocytiopsis humicola是必不可少的,而CLEC-26/CLEC-36对检测Haptoglossa zoospora是必需的。这两个 clec 对通过共享启动子受保守的 PRD 类同源基因转录因子 CEH-37/OTX2 的转录调控,并在感觉神经元和前肠中发挥作用,触发表皮的保护性免疫反应。该系统通过典型的 CLEC 受体实现了对卵菌威胁的冗余组织感应,并通过跨组织通信实现了宿主防御。
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Paired C-type lectin receptors mediate specific recognition of divergent oomycete pathogens in C. elegans.
Innate immune responses can be initiated through the detection of pathogen or damage-associated molecular patterns by host receptors that are often present on the surface of immune cells. While certain invertebrates like Caenorhabditis elegans lack professional immune cells, they still respond to infection in a pathogen-specific manner. It has been debated for years whether homologues of the canonical pathogen recognition receptors are also functioning in the nematode. Here we show that C-type lectin receptors mediate species-specific recognition of divergent oomycetes in C. elegans. A CLEC-27/CLEC-35 pair is essential for recognition of the oomycete Myzocytiopsis humicola, while a CLEC-26/CLEC-36 pair is required for detection of Haptoglossa zoospora. Both clec pairs are transcriptionally regulated through a shared promoter by the conserved PRD-like homeodomain transcription factor CEH-37/OTX2 and act in sensory neurons and the anterior intestine to trigger a protective immune response in the epidermis. This system enables redundant tissue sensing of oomycete threats through canonical CLEC receptors and host defense via cross-tissue communication.
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