病毒性腹泻--诊断和治疗的新进展。

IF 3.6 3区 医学 Q2 INFECTIOUS DISEASES Current Opinion in Infectious Diseases Pub Date : 2024-08-01 DOI:10.1097/qco.0000000000001053
J Gonzalo Acevedo-Rodriguez,Carmen A Contreras,Theresa J Ochoa
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引用次数: 0

摘要

综述目的 病毒是儿童腹泻最常见的病原体。尽管引入了轮状病毒疫苗,但轮状病毒仍是导致全球儿童死亡的主要病因,其次是诺如病毒,这给诊断带来了挑战。尽管免疫测定因其快速、低成本而被广泛使用,但分子技术因其高灵敏度和分析胃肠道中多种病原体的能力而成为最可靠的诊断方法。等温核酸扩增检测(LAMP 和 RPA)不需要复杂的设备,可用作床旁检测,因此是很有前途的技术。CRISPR/Cas 核酸检测系统是极具潜力的新型诊断方法。最近发表的几篇文章介绍了人类肠道肠道病毒在描述诺如病毒感染特征、测试新药和开发疫苗方面的作用。总结 尽管已经取得了重要进展,但仍需开展更多研究,以应对仍然存在的挑战,并进一步提高诊断能力和改善这一重要传染病的管理策略。
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Viral diarrheas - newer advances in diagnosis and management.
PURPOSE OF REVIEW Viruses are the most common etiological agents of diarrhea in children. Despite rotavirus vaccine introduction, rotavirus remains as the leading cause of death globally, followed by norovirus, which represents a diagnostic challenge. Here, we describe new advances in the diagnosis and management of viral diarrheas. RECENT FINDINGS Although immunoassays are widely used for their fast turnaround time and low cost, molecular techniques have become the most reliable diagnostic method due to their high sensitivity and capacity to analyze multiple pathogens in gastrointestinal panels. Isothermal nucleic acid amplification assays (LAMP and RPA) are promising techniques since they do not require sophisticated equipment and can be used as point-of-care testing. CRISPR/Cas nucleic acid detection systems are new diagnostic methods with great potential. Several recent published articles describe the role of human intestinal enteroids to characterize norovirus infection, to test new drugs, and for vaccine development. The interaction between the human gut microbiota and gastrointestinal viral infections has been extensively reviewed and offers some innovative mechanisms for therapeutic and preventive measures. SUMMARY Although important advances have been made, more research is needed to address remaining challenges and further improve diagnostic capabilities and better management strategies for this critical infectious disease.
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来源期刊
CiteScore
6.70
自引率
2.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
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