Lea Lackner,Birgit-Christiane Zyriax,Brigitte Stephan
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引用次数: 0
摘要
维生素 D 在炎症性皮肤病中发挥作用,并能改善这些疾病。化脓性扁桃体炎(HS)是一种自身炎症性慢性皮肤病,大多数患者表现出维生素 D 过低。2023 年 9 月 4 日,我们对 PubMed 和 Web of Science 进行了系统性文献检索。纳入了调查维生素 D 及其对 HS 严重程度潜在影响的研究。定性综述共纳入了 7 项研究,共计 575 名患者,其中 3 项采用横断面设计,2 项为试点研究,1 项为对照队列研究,1 项为前瞻性病例对照研究。在所有纳入的研究中,HS 患者均缺乏维生素 D。有证据表明,血清维生素 D 水平与疾病的严重程度呈负相关,至少有提示性证据表明,补充维生素 D 可对 HS 的病程产生积极影响。为了更好地了解这些相关性,就维生素 D 及其对 HS 严重程度的影响开展随机对照试验研究势在必行。
To what Extent does Vitamin D and its Serum Levels Influence the Severity of Hidradenitis Suppurativa: A Literature Review.
Vitamin D plays a role in inflammatory skin conditions and can improve them. Hidradenitis suppurativa (HS) is an autoinflammatory chronic skin disease in which most patients exhibit a hypovitaminosis D. However, it is uncertain whether vitamin D supplementation could relieve the severity of HS. A systematic literature search of PubMed and Web of Science was conducted on 4 September 2023. Studies that investigated vitamin D and its potential implications for the severity of HS were included. In contrast, studies that focused on the prevalence of vitamin D deficiency were excluded, as well as studies on syndromic HS. Seven studies with a total of 575 patients were included in the qualitative synthesis, of which 3 utilized a cross-sectional design, 2 were pilot studies, 1 a controlled cohort study, and 1 a prospective case-control study. In all included studies, HS patients were vitamin D deficient. There was evidence indicating that serum vitamin D levels negatively correlated with the severity of the disease, and at least suggestive evidence that vitamin D supplementation could have a positive impact on the course of HS. To better understand these correlations, conducting a randomized controlled trial study on vitamin D and its effects on HS severity is imperative.
期刊介绍:
Acta Dermato-Venereologica publishes high-quality manuscripts in English in the field of Dermatology and Venereology, dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of Review articles in special areas, as well as short Letters to the Editor to stimulate debate and to disseminate important clinical observations. Acta Dermato-Venereologica has rapid publication times and is amply illustrated with a large number of colour photographs.