在掺硼金刚石薄膜电极上使用伏安法和流动注射分析法检测双氯芬酸和卡马西平

IF 2.7 3区化学 Q2 CHEMISTRY, ANALYTICAL Electroanalysis Pub Date : 2024-09-04 DOI:10.1002/elan.202400157

Aaron Jacobs, Simphiwe Zwane, Romana Jarošová, Marissa D. Zamora, Alex Kuvarega, Greg Swain

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引用次数: 0

摘要

研究人员使用掺硼纳米晶金刚石（BDD）薄膜电极，以氧化电流的形式对双氯芬酸（DCF）和卡马西平（CBZ）这两种药物进行了电化学检测。伏安法和安培检测流动注射分析法（FIA-EC）用于测量标准溶液和尿液模拟物中的药物。在 0.1 M 磷酸盐缓冲液（pH 7.2）中，DCF 对 Ag/AgCl（3 M KCl）的氧化电位为 0.8 V；在 0.1 M 高氯酸中，CBZ 的氧化电位为 1.2 V。在检测电位下，DCF 的氧化反应是扩散控制的，但有证据表明，CBZ 在 0.1 M 高氯酸中会产生一些表面污垢。

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Detection of Diclofenac and Carbamazepine using Voltammetry and Flow Injection Analysis at Boron‐Doped Diamond Thin‐Film Electrodes

The electrochemical detection of two pharmaceuticals, diclofenac (DCF) and carbamazepine (CBZ), was investigated as an oxidation current using boron‐doped nanocrystalline diamond (BDD) thin‐film electrodes. Both voltammetry and flow injection analysis with amperometric detection (FIA‐EC) were used to measure the drugs in standard solutions and a urine simulant. The oxidation potential of DCF was ca. 0.8 V vs. Ag/AgCl (3 M KCl) in 0.1 M phosphate buffer (pH 7.2) and was ca. 1.2 V for CBZ in 0.1 M perchloric acid. The DCF oxidation reaction was diffusion controlled at the detection potential with evidence of some surface fouling by

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来源期刊

Electroanalysis 化学-电化学

CiteScore

6.00

自引率

3.30%

发文量

222

审稿时长

2.4 months

期刊介绍： Electroanalysis is an international, peer-reviewed journal covering all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with new electrochemical sensors and biosensors, nanobioelectronics devices, analytical voltammetry, potentiometry, new electrochemical detection schemes based on novel nanomaterials, fuel cells and biofuel cells, and important practical applications. Serving as a vital communication link between the research labs and the field, Electroanalysis helps you to quickly adapt the latest innovations into practical clinical, environmental, food analysis, industrial and energy-related applications. Electroanalysis provides the most comprehensive coverage of the field and is the number one source for information on electroanalytical chemistry, electrochemical sensors and biosensors and fuel/biofuel cells.

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