{"title":"利用低温加工的 Ag-TiO2 双功能涂层对医用生物材料进行表面改性,以防止生物膜的形成","authors":"Lipi Pradhan, Sobhan Hazra, Satya Veer Singh, Bajrang, Anjali Upadhyay, Bhola Nath Pal, Sudip Mukherjee","doi":"10.1039/d4tb00701h","DOIUrl":null,"url":null,"abstract":"Biofilm development in medical devices is considered the major virulence component that leads to increased mortality and morbidity among patients. Removing a biofilm once formed is challenging and frequently results in persistent infections. Many current antibiofilm coating strategies involve harsh conditions causing damage to the surface of the medical devices. To address the issue of bacterial attachment in medical devices, we propose a novel antibacterial surface modification approach. In this paper, we developed a novel low-temperature based solution-processed approach to deposit silver nanoparticles (Ag NPs) inside a titanium oxide (TiO<small><sub>2</sub></small>) matrix to obtain a Ag–TiO<small><sub>2</sub></small> nanoparticle coating. The low temperature (120 °C)-based UV annealed drop cast method is novel and ensures no surface damage to the medical devices. Various medical-grade biomaterials were then coated using Ag–TiO<small><sub>2</sub></small> to modify the surface of the materials. Several studies were performed to observe the antibacterial and antibiofilm properties of Ag–TiO<small><sub>2</sub></small>-coated medical devices and biomaterials. Moreover, the Ag–TiO<small><sub>2</sub></small> NPs did not show any skin irritation in rats and showed biocompatibility in the chicken egg model. This study indicates that Ag–TiO<small><sub>2</sub></small> coating has promising potential for healthcare applications to combat microbial infection and biofilm formation.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Surface modification of medical grade biomaterials by using a low-temperature-processed dual functional Ag–TiO2 coating for preventing biofilm formation\",\"authors\":\"Lipi Pradhan, Sobhan Hazra, Satya Veer Singh, Bajrang, Anjali Upadhyay, Bhola Nath Pal, Sudip Mukherjee\",\"doi\":\"10.1039/d4tb00701h\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Biofilm development in medical devices is considered the major virulence component that leads to increased mortality and morbidity among patients. Removing a biofilm once formed is challenging and frequently results in persistent infections. Many current antibiofilm coating strategies involve harsh conditions causing damage to the surface of the medical devices. To address the issue of bacterial attachment in medical devices, we propose a novel antibacterial surface modification approach. In this paper, we developed a novel low-temperature based solution-processed approach to deposit silver nanoparticles (Ag NPs) inside a titanium oxide (TiO<small><sub>2</sub></small>) matrix to obtain a Ag–TiO<small><sub>2</sub></small> nanoparticle coating. The low temperature (120 °C)-based UV annealed drop cast method is novel and ensures no surface damage to the medical devices. Various medical-grade biomaterials were then coated using Ag–TiO<small><sub>2</sub></small> to modify the surface of the materials. Several studies were performed to observe the antibacterial and antibiofilm properties of Ag–TiO<small><sub>2</sub></small>-coated medical devices and biomaterials. Moreover, the Ag–TiO<small><sub>2</sub></small> NPs did not show any skin irritation in rats and showed biocompatibility in the chicken egg model. This study indicates that Ag–TiO<small><sub>2</sub></small> coating has promising potential for healthcare applications to combat microbial infection and biofilm formation.\",\"PeriodicalId\":83,\"journal\":{\"name\":\"Journal of Materials Chemistry B\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2024-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Materials Chemistry B\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1039/d4tb00701h\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Chemistry B","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1039/d4tb00701h","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Surface modification of medical grade biomaterials by using a low-temperature-processed dual functional Ag–TiO2 coating for preventing biofilm formation
Biofilm development in medical devices is considered the major virulence component that leads to increased mortality and morbidity among patients. Removing a biofilm once formed is challenging and frequently results in persistent infections. Many current antibiofilm coating strategies involve harsh conditions causing damage to the surface of the medical devices. To address the issue of bacterial attachment in medical devices, we propose a novel antibacterial surface modification approach. In this paper, we developed a novel low-temperature based solution-processed approach to deposit silver nanoparticles (Ag NPs) inside a titanium oxide (TiO2) matrix to obtain a Ag–TiO2 nanoparticle coating. The low temperature (120 °C)-based UV annealed drop cast method is novel and ensures no surface damage to the medical devices. Various medical-grade biomaterials were then coated using Ag–TiO2 to modify the surface of the materials. Several studies were performed to observe the antibacterial and antibiofilm properties of Ag–TiO2-coated medical devices and biomaterials. Moreover, the Ag–TiO2 NPs did not show any skin irritation in rats and showed biocompatibility in the chicken egg model. This study indicates that Ag–TiO2 coating has promising potential for healthcare applications to combat microbial infection and biofilm formation.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices