Lucas Sejournet, Thibaud Mathis, Victor Vermot-Desroches, Rita Serra, Ines Fenniri, Philippe Denis, Laurent Kodjikian
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引用次数: 0
摘要
糖尿病黄斑水肿(DME)是糖尿病视网膜病变的常见并发症。玻璃体内注射治疗对大多数病例有效,但患者的治疗负担较重。这意味着需要长期治疗,如植入氟西诺龙醋酸酯(FAc)。我们对基础科学、药理学和临床数据进行了回顾,以提供 2024 年 FAc 植入物的最新观点。虽然 FAc 植入物的耐受性普遍良好,但它也与眼压过高和白内障有关,因此建议患者谨慎使用。通过综合这些领域的信息,可以获得全面的评估结果,有助于在使用 FAc 植入体治疗 DME 方面做出明智的决策。本综述的主要目的是为临床医生提供指导,帮助他们了解如何在二重性视网膜病变患者中引入和使用FAc植入体。
Efficacy and Safety of Fluocinolone Acetonide Implant in Diabetic Macular Edema: Practical Guidelines from Reference Center
Diabetic macular edema (DME) is a common complication of diabetic retinopathy. Treatment with intravitreal injections is effective in most cases but is associated with a high therapeutic burden for patients. This implies the need for long-term treatments, such as the fluocinolone acetonide (FAc) implant. A review of basic science, pharmacology, and clinical data was conducted to provide a state-of-the-art view of the FAc implant in 2024. Although generally well tolerated, the FAc implant has been associated with ocular hypertension and cataract, and caution should be advised to the patients in this regard. By synthesizing information across these domains, a comprehensive evaluation can be attained, facilitating informed decision-making regarding the use of the FAc implant in the management of DME. The main objective of this review is to provide clinicians with guidelines on how to introduce and use the FAc implant in a patient with DME.
PharmaceuticsPharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍:
Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications, and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.