含透明质酸的巴西莓油基有机凝胶用于局部美容:体外和体内评估

IF 4.9 3区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmaceutics Pub Date : 2024-09-11 DOI:10.3390/pharmaceutics16091195
Suellen Christtine da Costa Sanches, Lindalva Maria de Meneses Costa Ferreira, Rayanne Rocha Pereira, Desireé Gyles Lynch, Ingryd Nayara de Farias Ramos, André Salim Khayat, José Otávio Carrera Silva-Júnior, Alessandra Rossi, Roseane Maria Ribeiro-Costa
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引用次数: 0

摘要

有机凝胶是一种半固体药物形式,其分散相为有机液体,如油,如巴西莓油,被胶凝剂形成的三维网络固定。有机凝胶作为化妆品活性成分(如用于局部应用的透明质酸)的创新释放系统而备受关注。对巴西莓油的理化参数、脂肪酸组成、脂质指数、光谱模式(衰减全反射傅立叶变换红外光谱)、热行为、总酚、总类黄酮、总类胡萝卜素和β-胡萝卜素含量进行了评估。通过体外渗透和皮肤保留测试、体外tentenuated total reflectance Fourier Transform Infrared Spectroscopy 和差示扫描量热法测试,对添加了透明质酸(OG + HA)的有机凝胶的功效进行了评估。理化分析结果表明,巴西莓油符合监管机构的质量标准。巴西莓油还显示出很高的抗氧化能力,这与已确定的生物活性化合物有关。细胞毒性测试表明,OG + HA 配方不会向生物环境释放有毒物质,从而阻碍细胞的生长、粘附和功效。体外和体内分析表明,涂抹 6 小时后,OG + HA 具有较高的水合作用、热保护作用和 HA 释放作用。因此,可以得出这样的结论:OG + HA 配方具有物理化学应用潜力、抗氧化质量以及在化妆品领域应用的潜在功效。
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Acai Oil-Based Organogel Containing Hyaluronic Acid for Topical Cosmetic: In Vitro and Ex Vivo Assessment
Organogels are semi-solid pharmaceutical forms whose dispersing phase is an organic liquid, for example, an oil, such as acai oil, immobilized by a three-dimensional network formed by the gelling agent. Organogels are being highlighted as innovative release systems for cosmetic active ingredients such as hyaluronic acid for topical applications. Acai oil was evaluated for its physicochemical parameters, fatty acid composition, lipid quality index, spectroscopic pattern (Attenuated total reflectance Fourier Transform Infrared Spectroscopy), thermal behavior, total phenolic, total flavonoids, and total carotenoids and β-carotene content. The effectiveness of the organogel incorporated with hyaluronic acid (OG + HA) was evaluated through ex vivo permeation and skin retention tests, in vitro tests by Attenuated total reflectance Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry. The physicochemical analyses highlighted that the acai oil exhibited quality standards in agreement with the regulatory bodies. Acai oil also showed high antioxidant capacity, which was correlated with the identified bioactive compounds. The cytotoxicity tests demonstrated that the formulation OG + HA does not release toxic substances into the biological environment that could impede cell growth, adhesion, and efficacy. In vitro and ex vivo analyses demonstrated that after 6 h of application, OG + HA presented a high level of hydration, thermal protection and release of HA. Thus, it can be concluded that the OG + HA formulation has the potential for physical–chemical applications, antioxidant quality, and potentially promising efficacy for application in the cosmetic areas.
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来源期刊
Pharmaceutics
Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍: Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications,  and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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