间歇性缺氧训练--外泌体在中风康复中的应用

IF 2.6 3区医学 Q2 BEHAVIORAL SCIENCES Frontiers in Integrative Neuroscience Pub Date : 2024-09-11 DOI:10.3389/fnint.2024.1475234

Myoung-Gwi Ryou, Summer Burton

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引用次数: 0

摘要

在美国，缺血性中风是导致成人残疾的第四大原因，也是全世界巨大的社会负担。然而，缺血性中风并没有有效的治疗方法。未能找到或开发出治疗缺血性中风的干预措施的一个明显原因是血脑屏障（BBB）的严密性。研究缺血性中风干预措施的研究人员强调了外泌体可以穿越 BBB 的独特特性。此外，间歇性缺氧训练也被认为是缺血性中风患者治疗或康复过程中的一种潜在干预措施。在这篇微型综述中，我们将探讨在缺血性中风的治疗方案中应用进行间歇性缺氧训练的受试者产生的外泌体的可能性。

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Intermittent hypoxic training – derived exosomes in stroke rehabilitation

Ischemic stroke is the fourth leading cause of adult disability in the US, and it is a huge social burden all over the world. However, the efficient treatment of ischemic stroke is not available. An apparent reason for failing to find or develop an intervention for ischemic stroke is contributed to the tight blood–brain barrier (BBB). The unique characteristics of exosomes that can traverse BBB have been highlighted among researchers investigating interventions for ischemic stroke conditions. Additionally, intermittent hypoxic training has been considered a potential intervention in the treatment or rehabilitation process of ischemic stroke patients. In this mini-review, we are going to review the possibility of applying exosomes produced by a subject who does intermittent hypoxic conditioning in a treatment program for ischemic stroke.

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来源期刊

Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience

CiteScore

4.60

自引率

2.90%

发文量

148

审稿时长

14 weeks

期刊介绍： Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.