Nazar Mohd Azahar, Mohamad Rodi Isa, Mizuki Ohashi, Yuichiro Yano
{"title":"波浪导航:了解从童年到成年的血压振幅和节律变化","authors":"Nazar Mohd Azahar, Mohamad Rodi Isa, Mizuki Ohashi, Yuichiro Yano","doi":"10.1038/s41371-024-00953-y","DOIUrl":null,"url":null,"abstract":"<p>The circadian rhythm regulates individuals’ blood pressure (BP) and heart rate. It is significantly linked with cardiovascular physiology and diseases. Any abnormalities in these rhythms may lead to sleep problems, several adverse cardiovascular events [1], cardiorenal outcomes and an increased risk of cardiovascular mortality [2]. This circadian mechanism such as awake or sleep, autonomic nervous system cycles and pineal gland melatonin synthesis are the factors regulating the 24-h BP profile [3]. Understanding their role could pave the way for tailored treatments targeting circadian BP dysregulation and hypertension [2].</p><p>Circadian rhythm of BP during childhood and adulthood is crucial for the early diagnosis of cardiovascular diseases and to avert complications [4]. As we traverse life from childhood to adulthood, our bodies undergo a remarkable symphony of changes. Among these transformations, the subtle yet important variability in BP rhythm amplitude and percent rhythm changes play a significant role in shaping our cardiovascular health. The rhythm amplitude of BP refers to the distance between the highest value of the cosine curve and the BP midline estimating statistic of rhythm (BP mesor) [5]. This BP rhythm amplitude represents the extent of range from the peak BP levels to the average BP level over 24 h. An elevated BP rhythm amplitude signifies substantial differences between the highest BP readings and the BP mesor over 24-h period. This condition is often associated with dipping BP pattern and lower nocturnal BP levels. In childhood, this rhythm amplitude undergoes a gradual refinement as the cardiovascular system matures. As age progresses, pulse amplitude increases impacting the carotid, radial and femoral arteries [6]. Children who are in the highest systolic and diastolic BP trajectories (i.e., high BP in the early period and remained elevated) had a significantly higher risk of developing elevated BP during early adulthood [7]. Similar to BP trajectories, BP rhythm amplitude also demonstrates the potential for predicting future hypertension and cardiovascular events [8]. These findings imply that BP during childhood and adolescence may predict the occurrence of elevated BP in adulthood. On the other hand, lower percent rhythm changes implicate a dampened rhythm of the heartbeat [9]. The heart’s rhythm is orchestrated by a delicate interplay of electrical signals, and during childhood, it undergoes a process of fine-tuning. The transition from childhood to adolescence is marked by a decrease in heart rate, reflecting the maturation of the cardiovascular system. This shift is indicative of a more efficient heart, capable of pumping blood with increased precision and less effort.</p>","PeriodicalId":16070,"journal":{"name":"Journal of Human Hypertension","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Navigating the waves: understanding blood pressure amplitude and rhythm changes from childhood to adulthood\",\"authors\":\"Nazar Mohd Azahar, Mohamad Rodi Isa, Mizuki Ohashi, Yuichiro Yano\",\"doi\":\"10.1038/s41371-024-00953-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The circadian rhythm regulates individuals’ blood pressure (BP) and heart rate. It is significantly linked with cardiovascular physiology and diseases. Any abnormalities in these rhythms may lead to sleep problems, several adverse cardiovascular events [1], cardiorenal outcomes and an increased risk of cardiovascular mortality [2]. This circadian mechanism such as awake or sleep, autonomic nervous system cycles and pineal gland melatonin synthesis are the factors regulating the 24-h BP profile [3]. Understanding their role could pave the way for tailored treatments targeting circadian BP dysregulation and hypertension [2].</p><p>Circadian rhythm of BP during childhood and adulthood is crucial for the early diagnosis of cardiovascular diseases and to avert complications [4]. As we traverse life from childhood to adulthood, our bodies undergo a remarkable symphony of changes. Among these transformations, the subtle yet important variability in BP rhythm amplitude and percent rhythm changes play a significant role in shaping our cardiovascular health. The rhythm amplitude of BP refers to the distance between the highest value of the cosine curve and the BP midline estimating statistic of rhythm (BP mesor) [5]. This BP rhythm amplitude represents the extent of range from the peak BP levels to the average BP level over 24 h. An elevated BP rhythm amplitude signifies substantial differences between the highest BP readings and the BP mesor over 24-h period. This condition is often associated with dipping BP pattern and lower nocturnal BP levels. In childhood, this rhythm amplitude undergoes a gradual refinement as the cardiovascular system matures. As age progresses, pulse amplitude increases impacting the carotid, radial and femoral arteries [6]. Children who are in the highest systolic and diastolic BP trajectories (i.e., high BP in the early period and remained elevated) had a significantly higher risk of developing elevated BP during early adulthood [7]. Similar to BP trajectories, BP rhythm amplitude also demonstrates the potential for predicting future hypertension and cardiovascular events [8]. These findings imply that BP during childhood and adolescence may predict the occurrence of elevated BP in adulthood. On the other hand, lower percent rhythm changes implicate a dampened rhythm of the heartbeat [9]. The heart’s rhythm is orchestrated by a delicate interplay of electrical signals, and during childhood, it undergoes a process of fine-tuning. The transition from childhood to adolescence is marked by a decrease in heart rate, reflecting the maturation of the cardiovascular system. 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Navigating the waves: understanding blood pressure amplitude and rhythm changes from childhood to adulthood
The circadian rhythm regulates individuals’ blood pressure (BP) and heart rate. It is significantly linked with cardiovascular physiology and diseases. Any abnormalities in these rhythms may lead to sleep problems, several adverse cardiovascular events [1], cardiorenal outcomes and an increased risk of cardiovascular mortality [2]. This circadian mechanism such as awake or sleep, autonomic nervous system cycles and pineal gland melatonin synthesis are the factors regulating the 24-h BP profile [3]. Understanding their role could pave the way for tailored treatments targeting circadian BP dysregulation and hypertension [2].
Circadian rhythm of BP during childhood and adulthood is crucial for the early diagnosis of cardiovascular diseases and to avert complications [4]. As we traverse life from childhood to adulthood, our bodies undergo a remarkable symphony of changes. Among these transformations, the subtle yet important variability in BP rhythm amplitude and percent rhythm changes play a significant role in shaping our cardiovascular health. The rhythm amplitude of BP refers to the distance between the highest value of the cosine curve and the BP midline estimating statistic of rhythm (BP mesor) [5]. This BP rhythm amplitude represents the extent of range from the peak BP levels to the average BP level over 24 h. An elevated BP rhythm amplitude signifies substantial differences between the highest BP readings and the BP mesor over 24-h period. This condition is often associated with dipping BP pattern and lower nocturnal BP levels. In childhood, this rhythm amplitude undergoes a gradual refinement as the cardiovascular system matures. As age progresses, pulse amplitude increases impacting the carotid, radial and femoral arteries [6]. Children who are in the highest systolic and diastolic BP trajectories (i.e., high BP in the early period and remained elevated) had a significantly higher risk of developing elevated BP during early adulthood [7]. Similar to BP trajectories, BP rhythm amplitude also demonstrates the potential for predicting future hypertension and cardiovascular events [8]. These findings imply that BP during childhood and adolescence may predict the occurrence of elevated BP in adulthood. On the other hand, lower percent rhythm changes implicate a dampened rhythm of the heartbeat [9]. The heart’s rhythm is orchestrated by a delicate interplay of electrical signals, and during childhood, it undergoes a process of fine-tuning. The transition from childhood to adolescence is marked by a decrease in heart rate, reflecting the maturation of the cardiovascular system. This shift is indicative of a more efficient heart, capable of pumping blood with increased precision and less effort.
期刊介绍:
Journal of Human Hypertension is published monthly and is of interest to health care professionals who deal with hypertension (specialists, internists, primary care physicians) and public health workers. We believe that our patients benefit from robust scientific data that are based on well conducted clinical trials. We also believe that basic sciences are the foundations on which we build our knowledge of clinical conditions and their management. Towards this end, although we are primarily a clinical based journal, we also welcome suitable basic sciences studies that promote our understanding of human hypertension.
The journal aims to perform the dual role of increasing knowledge in the field of high blood pressure as well as improving the standard of care of patients. The editors will consider for publication all suitable papers dealing directly or indirectly with clinical aspects of hypertension, including but not limited to epidemiology, pathophysiology, therapeutics and basic sciences involving human subjects or tissues. We also consider papers from all specialties such as ophthalmology, cardiology, nephrology, obstetrics and stroke medicine that deal with the various aspects of hypertension and its complications.