二肽基肽酶 4 抑制剂对 2 型糖尿病患者急性呼吸衰竭风险的影响:心血管结局试验的荟萃分析

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine journal Pub Date : 2024-09-12 DOI:10.1507/endocrj.ej24-0164
Yan Wang, Caiyuan Yu, Xiaoyan Zheng, Yaya Wang, Wei Zhang
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引用次数: 0

摘要

二肽基肽酶 4(DPP-4)抑制剂是一种新型抗糖尿病药物。它们对呼吸系统的影响尚不清楚。本研究旨在确定二肽基肽酶 4 抑制剂与 2 型糖尿病(T2DM)患者急性呼吸衰竭(ARF)之间的关系。研究人员通过检索 PubMed、Embase 和 CENTRAL 数据库(截至 2024 年 7 月 3 日),对纳入 T2DM 患者的随机对照、双盲和安慰剂对照心血管结局试验(CVOT)进行了荟萃分析。最初共检索到 6532 项研究,最终有 5 项大型 CVOT 纳入了荟萃分析,共纳入了 47714 名 T2DM 成年患者。总体而言,与安慰剂组相比,DDP-4 抑制剂组的 ARF 风险增加不明显(RR,1.72;95% CI,0.59 至 4.97;P = 0.319)。这是首次评估 DDP-4 抑制剂与 T2DM 患者 ARF 之间关系的荟萃分析。总的来说,这些研究结果表明,DPP-4 抑制剂可能会轻微但非显著地增加 T2DM 患者发生 ARF 的风险。由于现有的研究较少,发生 ARF 事件的情况也不多,因此需要进一步开展设计良好的大规模研究。
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Effects of dipeptidyl peptidase 4 inhibitors on the risk of acute respiratory failure in patients with type 2 diabetes mellitus: a meta-analysis of cardiovascular outcomes trials

Dipeptidyl peptidase 4 (DPP-4) inhibitors are new antidiabetic drugs. Their effects on the respiratory system remain unclear. This study aimed to determine the association between DDP-4 inhibitors and acute respiratory failure (ARF) among patients with type 2 diabetes mellitus (T2DM). A meta-analysis was performed by searching the PubMed, Embase, and CENTRAL databases up to July 3rd, 2024, to identify randomized controlled, double-blind, and placebo controlled-cardiovascular outcomes trials (CVOTs) that enrolled participants with T2DM. A total of 6,532 studies were initially retrieved; ultimately, 5 large CVOTs enrolling 47,714 adult T2DM patients were included in the meta-analysis. Overall, there were a nonsignificant increase in the risk of ARF in the DDP-4 inhibitor group compared with the placebo group (RR, 1.72; 95% CI, 0.59 to 4.97; p = 0.319). This is the first meta-analysis to evaluate the association between DDP-4 inhibitors and ARF among T2DM patients. In general, these findings suggest that DPP-4 inhibitors may slightly, but non-significantly, increase the risk of ARF in T2DM patients. As few studies are available and few ARF events occurred, further well-designed large-scale studies need to be performed.

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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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