骨关节炎中的铜代谢及其与氧化应激和软骨细胞中的铁蛋白沉积的关系

IF 3.9 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Frontiers in Molecular Biosciences Pub Date : 2024-09-11 DOI:10.3389/fmolb.2024.1472492
Qingyuan Yu, Yanan Xiao, Mengqi Guan, Xianshuai Zhang, Jianan Yu, Mingze Han, Zhenhua Li
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引用次数: 0

摘要

铁变态反应是一种依赖铁离子的脂质过氧化过程,会破坏质膜,导致细胞非程序性死亡。骨关节炎(OA)是中老年人中普遍存在的一种慢性退行性关节疾病,其特点是软骨细胞受损或丧失。新近的证据表明,软骨细胞铁蛋白沉积在 OA 的发展过程中起着一定的作用。然而,大多数研究都集中于涉及典型铁离子的铁变态反应调节,可能忽视了 OA 患者血清和关节液中铜离子升高的重要性。本综述旨在通过系统研究 OA 中铜代谢、氧化应激、铁变态反应和铜相关细胞死亡之间的相互作用来填补这一空白。它将全面概述铜离子在调节铁变态反应中的作用及其在 OA 中的双重作用。这种方法旨在为进一步研究、预防和治疗 OA 提供新的见解。
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Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes
Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss. Emerging evidence indicates that chondrocyte ferroptosis plays a role in OA development. However, most research has concentrated on ferroptosis regulation involving typical iron ions, potentially neglecting the significance of elevated copper ions in both serum and joint fluid of patients with OA. This review aims to fill this gap by systematically examining the interplay between copper metabolism, oxidative stress, ferroptosis, and copper-associated cell death in OA. It will provide a comprehensive overview of copper ions’ role in regulating ferroptosis and their dual role in OA. This approach seeks to offer new insights for further research, prevention, and treatment of OA.
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来源期刊
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
7.20
自引率
4.00%
发文量
1361
审稿时长
14 weeks
期刊介绍: Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.
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