Talin-1的高表达与胰腺癌的低侵袭性肿瘤行为有关

Samira Ahmadi Jazi,Fatemeh Tajik,Fereshteh Rezagholizadeh,Seyed Reza Taha,Mahdieh Shariat Zadeh,Behnaz Bouzari,Zahra Madjd
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摘要

Talin-1 是局灶粘连中的主要支架蛋白之一,在细胞迁移、转移和癌症进展中发挥着重要作用。尽管有关 Talin-1 在癌症中重要性的研究发展迅速,但其在胰腺癌(PC)中的预后和诊断价值仍不令人满意。因此,本研究旨在探讨 Talin-1 在不同类型 PC 中的表达、临床意义以及预后和诊断价值。本研究应用生物信息学分析确定了Talin-1在PC肿瘤和邻近正常样本中表达的临床重要性和生物学作用。采用免疫组化(IHC)方法评估了Talin-1在190个PC样本(包括170个胰腺导管腺癌(PDAC)和20个胰腺神经内分泌肿瘤(PNET))以及24个邻近正常组织的组织芯片(TMAs)中的表达模式、临床意义、预后和诊断价值。结果表明,与邻近的正常组织相比,Talin-1 在肿瘤细胞中的表达上调。在 PDAC 样本中,Talin-1 细胞质表达较高与组织学分级较低之间存在统计学意义(P<0.001)。此外,我们的研究结果表明,在 PNET 样本中,Talin-1 的细胞质表达与复发呈反向显著相关(P=0.014)。在Talin-1的细胞质表达与生存结果和诊断准确性之间没有观察到明显的关联。总之,我们的观察结果表明,Talin-1 蛋白的细胞质水平越高,PC 样本中侵袭性较低的肿瘤行为就越明显。尽管如此,还需要进一步的研究来探讨 Talin-1 在胰腺癌中的预后、诊断价值和作用机制。
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Higher Expression of Talin-1 is Associated With Less Aggressive Tumor Behavior in Pancreatic Cancer.
Talin-1 is one of the major scaffold proteins in focal adhesions playing a vital role in cell migration, metastasis, and cancer progression. Although studies regarding the importance of Talin-1 in cancer have rapidly developed, its prognostic and diagnostic value still remain unsatisfying in pancreatic cancer (PC). Therefore, the present study aims to investigate the expression, clinical significance, as well as the prognostic and diagnostic value of Talin-1 in different types of PC. Bioinformatic analysis was applied to determine the clinical importance and biological role of Talin-1 expression in PC tumors and the normal adjacent samples. The expression patterns, clinical significance, prognosis, and diagnosis value of Talin-1 were evaluated in tissue microarrays (TMAs) of 190 PC samples including 170 pancreatic ductal adenocarcinoma (PDAC), and 20 pancreatic neuroendocrine tumors (PNET), along with 24 adjacent normal tissues using immunohistochemistry (IHC). The results indicated that the expression of Talin-1 was upregulated in tumor cells compared with adjacent normal tissues. A statistically significant association was observed between the higher cytoplasmic expression of Talin-1 and lower histologic grade (P<0.001) in PDAC samples. Further, our findings indicated an inverse significant correlation between cytoplasmic expression of Talin-1 and recurrence (P=0.014) in PNET samples. No significant association was observed between the cytoplasmic expression of Talin-1 and survival outcomes as well as diagnostic accuracy. In conclusion, our observations demonstrated that a higher cytoplasmic level of Talin-1 protein was significantly associated with less aggressive tumor behaviors in PC samples. Nevertheless, further investigations are required to explore the prognostic plus diagnostic value, and mechanism of action of Talin-1 in pancreatic cancer.
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