将循环细胞外囊泡作为心血管疾病诊断、预后和治疗的生物标记物

IF 2.8 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Frontiers in Cardiovascular Medicine Pub Date : 2024-09-02 DOI:10.3389/fcvm.2024.1425159
Dominika Bernáth-Nagy, Melek Sükran Kalinyaprak, Evangelos Giannitsis, Pál Ábrahám, Florian Leuschner, Norbert Frey, Jona Benjamin Krohn
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引用次数: 0

摘要

心血管疾病(CVD)是造成全球死亡的主要原因之一。因此,不断研究新的循环生物标志物对于改善不同心血管疾病的早期诊断和预后以及开发和完善治疗措施至关重要。细胞外囊泡(EV)具有作为诊断和预后标志物的巨大潜力,因为它们通过包裹细胞特异性分子来代表其母细胞,而这些分子的质量和数量会因细胞状态而不同。假设心血管系统的所有细胞类型都能向血液循环中释放EV,新出现的一组证据已对血清或血浆中的EV在心血管疾病中的潜在作用进行了研究。全面的研究揭示了在冠心病、心房颤动、心力衰竭或炎症性心脏病等常见心血管疾病的背景下,EV 数量和以 RNA、蛋白质和脂质形式存在的 EV 结合货物的变化,突出了它们在诊断和预后方面的相关性。在许多体外和体内模型中,EV 也显示出良好的治疗潜力。然而,将 EV 研究转化为临床前或临床环境已被证明具有挑战性。本综述旨在概述血清或血浆衍生 EV 领域最相关的研究。
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Circulating extracellular vesicles as biomarkers in the diagnosis, prognosis and therapy of cardiovascular diseases
Cardiovascular disease (CVD) ranks among the primary contributors to worldwide mortality. Hence, the importance of constant research on new circulating biomarkers for the improvement of early diagnosis and prognostication of different CVDs and the development and refinement of therapeutic measures is critical. Extracellular vesicles (EV) have a great potential as diagnostic and prognostic markers, as they represent their parent cell by enclosing cell-specific molecules, which can differ in quality and quantity based on cell state. Assuming that all cell types of the cardiovascular system are capable of releasing EV into circulation, an emerging body of evidence has investigated the potential role of serum- or plasma-derived EV in CVD. Comprehensive research has unveiled alterations in EV quantity and EV-bound cargo in the form of RNA, proteins and lipids in the context of common CVDs such as coronary artery disease, atrial fibrillation, heart failure or inflammatory heart diseases, highlighting their diagnostic and prognostic relevance. In numerous in vitro and in vivo models, EV also showed promising therapeutic potential. However, translation of EV studies to a preclinical or clinical setting has proven to be challenging. This review is intended to provide an overview of the most relevant studies in the field of serum or plasma-derived EV.
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来源期刊
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.80
自引率
11.10%
发文量
3529
审稿时长
14 weeks
期刊介绍: Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.
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