通过 CaCO3 纳米粒子增强骨肉瘤免疫疗法：为光动力疗法重塑肿瘤酸性和免疫微环境（Adv. Healthcare Mater.）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2024-09-12 DOI:10.1002/adhm.202470147

Yinghua Gao, Zhuoying Wang, Xinmeng Jin, Xiaoli Wang, Yining Tao, Shandeng Huang, Yun Wang, Yingqi Hua, Xuran Guo, Jing Xu, Zhengdong Cai

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摘要

骨肉瘤光免疫疗法

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Enhanced Osteosarcoma Immunotherapy via CaCO3 Nanoparticles: Remodeling Tumor Acidic and Immune Microenvironment for Photodynamic Therapy (Adv. Healthcare Mater. 23/2024)

Osteosarcoma Photoimmunotherapy

In article 2400538, Yingqi Hua, Xuran Guo, Jing Xu, Zhengdong Cai, and co-workers design a new multicombination strategy that reprograms the immunosuppressive tumor microenvironment and enhances the effect of photodynamic therapy for osteosarcoma treatment. The combination of A-NPs@(SHK+Ce6) with programmed cell death protein 1 demonstrates remarkable ability in eliminating distant tumors and promoting long-term immune memory function, thereby protecting against tumor rechallenge.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.