利用最小脚步间隙数据的短期频谱特征预测生物反馈步态训练的改进情况

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2024-08-28 DOI:10.3389/fbioe.2024.1417497
Nandini Sengupta, Rezaul Begg, Aravinda S. Rao, Soheil Bajelan, Catherine M. Said, Marimuthu Palaniswami
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引用次数: 0

摘要

脑卒中康复干预需要多次训练和反复评估,以评估训练带来的改善。基于生物反馈的跑步机训练通常需要 10 次或更多次的训练才能确定其效果。训练和评估过程需要花费时间、人力和成本,以确定训练是否产生积极效果。根据基线最小足间隙(MFC)数据预测步态训练的有效性将大有裨益,有可能节省资源、成本和患者时间。这项研究利用基于短期傅立叶变换(STFT)的 MFC 数据幅度谱,提出了预测生物反馈训练效果的新特征。与单纯的时域分析相比,这种方法能够跟踪非稳态动态并捕捉步间 MFC 值的波动,为高效处理提供了一种紧凑的表示方法。所提出的基于 STFT 的特征优于现有的小波、直方图和基于 Poincaré 的特征,其最大准确率为 95%,F1 得分为 96%,灵敏度为 93.33%,特异性为 100%。与从 MFC 序列中提取的描述性统计特征以及从 MFC 百分比指数序列中提取的音调和熵特征相比,所提出的特征也具有统计学意义(p<0.001)。研究发现,短期频谱成分和窗口平均值(DC 值)具有预测生物反馈训练成功与否的能力。低频区较高的频谱振幅和较低的方差表明改善的几率较低,而较低的频谱振幅和较高的方差则表明改善的几率较高。
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Predicting improvement in biofeedback gait training using short-term spectral features from minimum foot clearance data
Stroke rehabilitation interventions require multiple training sessions and repeated assessments to evaluate the improvements from training. Biofeedback-based treadmill training often involves 10 or more sessions to determine its effectiveness. The training and assessment process incurs time, labor, and cost to determine whether the training produces positive outcomes. Predicting the effectiveness of gait training based on baseline minimum foot clearance (MFC) data would be highly beneficial, potentially saving resources, costs, and patient time. This work proposes novel features using the Short-term Fourier Transform (STFT)-based magnitude spectrum of MFC data to predict the effectiveness of biofeedback training. This approach enables tracking non-stationary dynamics and capturing stride-to-stride MFC value fluctuations, providing a compact representation for efficient processing compared to time-domain analysis alone. The proposed STFT-based features outperform existing wavelet, histogram, and Poincaré-based features with a maximum accuracy of 95%, F1 score of 96%, sensitivity of 93.33% and specificity of 100%. The proposed features are also statistically significant (p<0.001) compared to the descriptive statistical features extracted from the MFC series and the tone and entropy features extracted from the MFC percentage index series. The study found that short-term spectral components and the windowed mean value (DC value) possess predictive capabilities regarding the success of biofeedback training. The higher spectral amplitude and lower variance in the lower frequency zone indicate lower chances of improvement, while the lower spectral amplitude and higher variance indicate higher chances of improvement.
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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