调节人体 L2/3 锥体神经元的 XOR 功能

IF 3.1 3区 工程技术 Q2 NEUROSCIENCES Cognitive Neurodynamics Pub Date : 2024-09-12 DOI:10.1007/s11571-024-10175-0
Yanheng Li, Ruiming Zhang, Xiaojuan Sun
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引用次数: 0

摘要

人类 L2/3 锥体神经元的顶端树突能够通过调节由钙离子介导的树突钙动作电位(dCaAPs)的振幅来执行 XOR 计算。是什么影响了这一特殊功能?这个问题至今没有答案。在这项研究中,我们采用了一种合理可行的还原方法,在保留人类 L2/3 锥体神经元详细功能特性的同时,成功地推导出了简化模型。利用基于电导的模型,我们操纵了简化模型中顶端树突的膜电位。我们的研究结果表明,钠传导(\({g}_{Na}\))和膜电容(\({C}_{m}\))的增加会减弱XOR功能,而钾传导(\({g}_{K}\))的调节在维持XOR功能方面表现出稳健性。进一步的分析表明,当单一通路被激活时,\({g}_{Na}\)和\({C}_{m}\)的增加会导致dCaAPs振幅的减小,而\({g}_{K}\)的增加对dCaAPs振幅的影响相对较小。总之,尽管钙离子在人类L2/3锥体神经元顶端树突进行XOR计算中起着关键作用,但其他离子通道的电导和膜电容也会影响这一功能。
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Regulation of XOR function of reduced human L2/3 pyramidal neurons

The apical dendrites of human L2/3 pyramidal neurons are capable of performing XOR computation by modulating the amplitude of dendritic calcium action potentials (dCaAPs) mediated by calcium ions. What influences this particular function? There is still no answer to this question. In this study, we employed a rational and feasible reduction method to successfully derive simplified models of human L2/3 pyramidal neurons while preserving their detailed functional properties. Using a conductance-based model, we manipulated the membrane potential of the apical dendrite in the simplified model. Our findings indicate that an increase in sodium conductance (\({g}_{Na}\)) and membrane capacitance (\({C}_{m}\)) weakens the XOR function, while regulation of potassium conductance (\({g}_{K}\)) demonstrates robustness in maintaining the XOR function. Further analysis reveals that when a single pathway is activated, an increase in \({g}_{Na}\) and \({C}_{m}\) leads to decrease in the amplitude of dCaAPs, whereas increasing \({g}_{K}\) has a relatively minor impact on dCaAPs amplitude. In conclusion, although calcium ions play a crucial role in enabling apical dendrites of human L2/3 pyramidal neurons to perform XOR computation, other ion channels’ conductance and membrane capacitance can also influence this function.

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来源期刊
Cognitive Neurodynamics
Cognitive Neurodynamics 医学-神经科学
CiteScore
6.90
自引率
18.90%
发文量
140
审稿时长
12 months
期刊介绍: Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models. The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome. The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged. 1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics. 2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages. 3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.
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