Quince Seed Mucilage Mediated Biosynthesis of Gold Nanoparticles: Analysis of Its Anti-prostate Cancer and Antioxidant Properties

Herein, we have devised a green protocol for the biogenicmadeAu NPs mediated over natural and biological macromolecules derived from Quince (Cydoniaoblonga) seed mucilage (QSM). The intrinsic phytomolecules were utilized as effective reducing agent for the gold ions under ultrasonic conditions. They also enabled the Au NPs to stabilize inherently by capping or encapsulation. The structure of the Au NPs/QSM bio-nanocomposite was analyzed using a range of physicochemical techniques, such as elemental mapping, TEM, FE-SEM, UV-Vis spectroscopy, EDS, and ICP. In medicinal therapeutics sector on human health the cancer treatment assumes an important segment. Furthermore, the material’s biological activity was assessed by examining its antioxidant and cytotoxic characteristics against cell lines of prostate carcinoma. DPPH radical scavenging experiments were used to evaluate the antioxidant potential of Au NPs/QSM, and the resulting IC₅₀ was determined to be 138.1 µg/mL.IC₅₀index of the Au NPs/QSM against PC3, NCI-H660, and LNCaP cell lines were evaluated as 253, 271 and 195 µg/mL, respectively. Au NPs/QSM was found to cause a dose-dependent reduction in the viability of a malignant prostate cell line. The antioxidant properties of recent nanoparticles appear to be the cause of their anti-human prostate carcinoma activity.