M. Pradeep, M. Vishnuvardhan, A. Ganesh, Gangadhar Thalari
{"title":"3-{1-[(1-芳基-1H-1,2,3-三唑-4-基)甲基]-1H-苯并咪唑-2-基}-2-(吡咯烷-1-基)喹啉衍生物的绿色合成与抗菌活性","authors":"M. Pradeep, M. Vishnuvardhan, A. Ganesh, Gangadhar Thalari","doi":"10.1134/s1070428024060186","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>A novel series of pyrrolidinylquinoline–imidazolyl-1,2,3-triazole hybrids were synthesised starting from 2-(pyrrolidine-1-yl)quinoline-3-carbaldehyde. The aldehyde was reacted with <i>o</i>-phenylenediamine to produce benzimidazole derivative which was alkylated with propargyl bromide and then subjected to copper-catalyzed azide–alkyne cycloaddition to afford the desired 1,2,3-triazole derivatives. The cycloaddition step was performed under both traditional stirring and microwave irradiation. All synthesized triazole derivatives were screened for their in vitro antimicrobial activity against various bacterial and fungal pathogens. The majority of the synthesized compounds demonstrated moderate to good inhibition zones compared to the standard drugs.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Green Synthesis and Antimicrobial Activity of 3-{1-[(1-Aryl-1H-1,2,3-triazol-4-yl)methyl]-1H-benzimidazol-2-yl}-2-(pyrrolidin-1-yl)quinoline Derivatives\",\"authors\":\"M. Pradeep, M. Vishnuvardhan, A. Ganesh, Gangadhar Thalari\",\"doi\":\"10.1134/s1070428024060186\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>A novel series of pyrrolidinylquinoline–imidazolyl-1,2,3-triazole hybrids were synthesised starting from 2-(pyrrolidine-1-yl)quinoline-3-carbaldehyde. The aldehyde was reacted with <i>o</i>-phenylenediamine to produce benzimidazole derivative which was alkylated with propargyl bromide and then subjected to copper-catalyzed azide–alkyne cycloaddition to afford the desired 1,2,3-triazole derivatives. The cycloaddition step was performed under both traditional stirring and microwave irradiation. All synthesized triazole derivatives were screened for their in vitro antimicrobial activity against various bacterial and fungal pathogens. The majority of the synthesized compounds demonstrated moderate to good inhibition zones compared to the standard drugs.</p>\",\"PeriodicalId\":766,\"journal\":{\"name\":\"Russian Journal of Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1134/s1070428024060186\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1134/s1070428024060186","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Green Synthesis and Antimicrobial Activity of 3-{1-[(1-Aryl-1H-1,2,3-triazol-4-yl)methyl]-1H-benzimidazol-2-yl}-2-(pyrrolidin-1-yl)quinoline Derivatives
Abstract
A novel series of pyrrolidinylquinoline–imidazolyl-1,2,3-triazole hybrids were synthesised starting from 2-(pyrrolidine-1-yl)quinoline-3-carbaldehyde. The aldehyde was reacted with o-phenylenediamine to produce benzimidazole derivative which was alkylated with propargyl bromide and then subjected to copper-catalyzed azide–alkyne cycloaddition to afford the desired 1,2,3-triazole derivatives. The cycloaddition step was performed under both traditional stirring and microwave irradiation. All synthesized triazole derivatives were screened for their in vitro antimicrobial activity against various bacterial and fungal pathogens. The majority of the synthesized compounds demonstrated moderate to good inhibition zones compared to the standard drugs.
期刊介绍:
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.