Jinghong Huang, Tianwei Xu, Yue Dai, Yueping Li, Raoping Tu
{"title":"慢性病数量与抑郁症状轨迹的年龄相关性差异:一项基于人群的队列研究","authors":"Jinghong Huang, Tianwei Xu, Yue Dai, Yueping Li, Raoping Tu","doi":"10.1186/s12889-024-19975-9","DOIUrl":null,"url":null,"abstract":"The number of chronic diseases has been associated with changes in depressive symptoms over time among middle-aged and older adults. This study aimed to explore the association between the number of chronic diseases and trajectories of depressive symptoms and the role of age in this association. A total of 12,974 middle-aged and older Chinese adults (≥ 45 years) participated in the China Health and Retirement Longitudinal Study (CHARLS) in waves 2011, 2013, 2015, 2018, and 2020. The number of chronic diseases was determined by self-reported hospital diagnosis of hypertension, dyslipidemia, diabetes, cancer, chronic lung diseases, liver disease, heart diseases, stroke, kidney diseases, digestive diseases, emotional, nervous, or psychiatric problems, memory-related disease, arthritis or rheumatism, asthma, and then obtaining the total number of chronic diseases. Depressive symptoms were measured by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10). Group-based trajectory modeling (GBTM) was adopted to capture the trajectories of depressive symptoms over time. Multinomial logistic regressions were conducted to examine the association between the number of chronic diseases and trajectories of depressive symptoms and the role of age in this association. Four distinct trajectories of depressive symptoms were observed in 34.68% individuals in mild, 40.76% in moderate, 19.41% in increasing, and 5.15% in severe group. Compared to participants without chronic diseases, those with one, two, three or more chronic diseases had a 1.81, 3, and 7.49-fold higher risk of developing severe depressive symptom trajectory, respectively. Moreover, the association between the number of chronic diseases and severe depressive symptoms trajectory differed by age (45–59 and ≥ 60 years) (P for interaction < 0.05). Participants with middle age may play a promoting role in the association between the number of chronic disease and severe depressive symptoms. 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引用次数: 0
摘要
慢性疾病的数量与中老年人抑郁症状随时间的变化有关。本研究旨在探讨慢性病数量与抑郁症状轨迹之间的关联,以及年龄在这种关联中的作用。共有12974名中国中老年人(≥45岁)参加了2011年、2013年、2015年、2018年和2020年的中国健康与退休纵向研究(CHARLS)。慢性病的数量是通过自报医院诊断的高血压、血脂异常、糖尿病、癌症、慢性肺病、肝病、心脏病、中风、肾病、消化系统疾病、情绪、神经或精神问题、记忆相关疾病、关节炎或风湿病、哮喘来确定的,然后得出慢性病的总数。抑郁症状采用 10 项流行病学研究中心抑郁量表(CESD-10)进行测量。采用基于群体的轨迹模型(GBTM)来捕捉抑郁症状随时间变化的轨迹。通过多项式逻辑回归研究慢性病数量与抑郁症状轨迹之间的关联以及年龄在这种关联中的作用。结果显示,34.68%的人属于轻度抑郁症状,40.76%的人属于中度抑郁症状,19.41%的人属于重度抑郁症状,5.15%的人属于重度抑郁症状。与没有慢性疾病的参与者相比,患有一种、两种、三种或三种以上慢性疾病的参与者出现严重抑郁症状轨迹的风险分别高出1.81倍、3倍和7.49倍。此外,慢性病数量与严重抑郁症状轨迹之间的关系因年龄(45-59 岁和≥60 岁)而异(交互作用 P <0.05)。中年参与者可能对慢性病数量与严重抑郁症状之间的关联起到促进作用。严重抑郁症状干预可能对中年人更有益。
Age-related differences in the number of chronic diseases in association with trajectories of depressive symptoms: a population-based cohort study
The number of chronic diseases has been associated with changes in depressive symptoms over time among middle-aged and older adults. This study aimed to explore the association between the number of chronic diseases and trajectories of depressive symptoms and the role of age in this association. A total of 12,974 middle-aged and older Chinese adults (≥ 45 years) participated in the China Health and Retirement Longitudinal Study (CHARLS) in waves 2011, 2013, 2015, 2018, and 2020. The number of chronic diseases was determined by self-reported hospital diagnosis of hypertension, dyslipidemia, diabetes, cancer, chronic lung diseases, liver disease, heart diseases, stroke, kidney diseases, digestive diseases, emotional, nervous, or psychiatric problems, memory-related disease, arthritis or rheumatism, asthma, and then obtaining the total number of chronic diseases. Depressive symptoms were measured by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10). Group-based trajectory modeling (GBTM) was adopted to capture the trajectories of depressive symptoms over time. Multinomial logistic regressions were conducted to examine the association between the number of chronic diseases and trajectories of depressive symptoms and the role of age in this association. Four distinct trajectories of depressive symptoms were observed in 34.68% individuals in mild, 40.76% in moderate, 19.41% in increasing, and 5.15% in severe group. Compared to participants without chronic diseases, those with one, two, three or more chronic diseases had a 1.81, 3, and 7.49-fold higher risk of developing severe depressive symptom trajectory, respectively. Moreover, the association between the number of chronic diseases and severe depressive symptoms trajectory differed by age (45–59 and ≥ 60 years) (P for interaction < 0.05). Participants with middle age may play a promoting role in the association between the number of chronic disease and severe depressive symptoms. The severe depressive symptoms intervention may be more beneficial for middle-aged adults.
期刊介绍:
BMC Public Health is an open access, peer-reviewed journal that considers articles on the epidemiology of disease and the understanding of all aspects of public health. The journal has a special focus on the social determinants of health, the environmental, behavioral, and occupational correlates of health and disease, and the impact of health policies, practices and interventions on the community.