Peng Chen, George Varghese P J, Keren Zhao, Jingjie Hu
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引用次数: 0
摘要
经导管动脉栓塞术是一种微创介入治疗方法,用于阻断肿瘤或异常组织区域的血液供应。微球(MS)是临床上最常用的栓塞剂之一。为了了解微球在动脉中的流动行为,必须对其机械特性进行系统研究。本研究采用同轴气流法合成了不同钙浓度的海藻酸钙 MS。其中添加了吲哚菁绿(ICG)作为荧光染料。通过研究形态、成像性、流变性和膨胀行为,考察了 ICG 浓度变化对微球的影响。然后,通过流变试验、原子力显微镜试验、溶血试验和血栓形成试验研究了氯化钙浓度变化对微球的影响。结果表明,ICG 浓度越高的微球荧光越持久,储存模量(G′)越低。氯化钙浓度越高,G′越高,而原子力显微镜测试获得的局部杨氏模量没有受到明显影响。含有和不含 ICG 的 MS 具有良好的血液相容性和血栓形成性。
Mechanical investigation of a Tandem embolization-visualization system for minimally invasive procedures
Transcatheter arterial embolization is a minimally invasive intervention process in which the blood supply to a tumor or an abnormal area of tissue is blocked. One of the most commonly used embolic agents in clinics is microsphere (MS). In order to understand the flow behavior of microspheres in arteries, it is essential to study their mechanical properties systematically. In this work, calcium-alginate MSs with varying calcium concentrations were synthesized using a coaxial airflow method. Indocyanine green (ICG) was added as a fluorescent dye. The effect of ICG concentration change on microspheres was investigated by studying morphology, imageability, rheology, and swelling behavior. Then the effect of calcium chloride concentration change on microspheres was studied by conducting rheological tests, atomic force microscopy tests, hemolysis assay, and thrombogenicity assay. Results showed that microspheres with higher ICG concentrations have longer lasting fluorescence and lower storage modulus (G′). Higher concentrations of calcium chloride led to higher G′, while the local Young's modulus obtained by AFM test was not significantly affected. The MSs with and without ICG showed good hemocompatibility and thrombogenicity.
期刊介绍:
The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials.
The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.