在无金属条件下使用 1,2-双（二苯基膦）乙烷 (dppe)/NBS 对苄基苯砜进行脱氧反应

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC Synthetic Communications Pub Date : 2024-09-14 DOI:10.1080/00397911.2024.2401135

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引用次数: 0

摘要

利用 1,2-双（二苯基膦）乙烷（dppe）和 NBS 的混合物作为有效的促进剂，开发出了苄基苯砜化学选择性脱氧生成相应硫化物的有效途径。这是首次在无金属条件下开发出多种苄基苯砜的脱氧反应。温和的反应条件、水溶性副产物的形成以及对多种官能团的耐受性促进了它在有机合成中的广泛应用。

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Deoxygenation of benzylphenyl sulfones using 1,2-bis(diphenylphosphino)ethane (dppe)/NBS under metal-free conditions

An efficient route for the chemoselective deoxygenation of benzylphenyl sulfones to the corresponding sulfides has been developed using a mixture of 1,2-bis(diphenylphosphino)ethane(dppe) and NBS as an effective promoter. This is the first development on the deoxygenation of diverse benzylphenyl sulfones under metal-free conditions. The mild reaction conditions, formation of the water soluble by-product and tolerance of a wide range of functional groups promote its broad applications in organic synthesis.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.