The effect of curcumin supplementation on endothelial function and blood pressure in patients with metabolic disorders: A meta-analysis of meta-analyses

Several interventional studies have revealed the beneficial impact of curcumin supplementation on blood pressure and endothelial function, but the findings are conflicting. Therefore, this study was conducted to investigate the effects of curcumin supplementation on blood pressure and endothelial function. A meta-analyses of randomized clinical trials were performed by searching PubMed, Embase, Scopus, and Web of Science were searched up to March 31, 2024. Random effects models were used to calculate weighted mean differences (WMD). Pooled estimates of 10 studies revealed that curcumin decreased diastolic blood pressure (DBP) [WMD = −0.94, 95 % CI: −1.59, −0.30; p = 0.004], pulse wave velocity (PWV) [WMD = −45.60, 95 % CI: −88.16, −3.04; p = 0.03, I² = 0.0 %, p = 0.59], and vascular cell adhesion molecule-1 (VCAM-1) [WMD = −39.19; 95 % CI: −66.15, −12.23, p =0.004; I²=73.0 %, p = 0.005] significantly, and increased flow-mediated dilation (FMD) [WMD = 1.64, 95 % CI: 1.06, 2.22; p < 0.001, I² = 0.0 %, p = 0.61. However, curcumin did not significantly change systolic blood pressure (SBP) [WMD = −0.64, 95 % CI: −1.96, 0.67; p =0.34, I² = 83.5 %, p <0.001], and Intercellular Adhesion Molecule 1 (ICAM1) [WMD = −17.05; 95 % CI: −80.79, 46.70, p =0.601; I²=94.1 %, p < 0.001]. These results suggest that curcumin has a beneficial effect on DBP, PWV, VCAM-1 and FMD levels and may be an effective adjunctive therapy for improving blood pressure and endothelial function.