糖尿病患者出现夏科氏足的风险因素

IF 8.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetologia Pub Date : 2024-09-13 DOI:10.1007/s00125-024-06271-9

Georgios Tsatsaris, Neda Rajamand Ekberg, Tove Fall, Sergiu-Bogdan Catrina

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引用次数: 0

摘要

目的/假说恰克脚是糖尿病的一种并发症，具有潜在的灾难性后果。虽然该病于 1868 年首次被描述，并于 1936 年被发现与糖尿病有关，但目前仍不确定影响该病发生的风险因素。在此，我们旨在通过一项全国性的队列研究来确定夏科足的风险因素。方法利用全国性的登记资料，对 2001-2016 年期间进行了一项基于登记资料的回顾性队列研究。根据糖尿病类型和相似的糖尿病持续时间，将患有糖尿病和夏科氏足的患者与患有糖尿病但未患有夏科氏足的患者进行配对。结果共纳入了 3397 名患有糖尿病和夏科脚的参与者，以及 27662 名患有糖尿病但没有夏科脚的对照参与者。HbA1c、糖尿病持续时间、微量和大量白蛋白尿、视网膜病变和动脉粥样硬化（全身和外周）被确定为1型糖尿病患者和2型糖尿病患者发生夏科脚的风险因素。结论/解释在迄今为止最广泛的夏科脚研究中，我们确定了与1型糖尿病患者和2型糖尿病患者发生夏科脚相关的独特和常见风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Risk factors for Charcot foot development in individuals with diabetes mellitus

Aims/hypothesis

Charcot foot is a complication of diabetes mellitus that has potentially disastrous consequences. Although it was first described in 1868 and found to be associated with diabetes in 1936, there is still uncertainty about the risk factors affecting the development of the condition. Here, we aim to identify risk factors for Charcot foot in a nationwide cohort study.

Methods

A retrospective register-based cohort study was performed for the period 2001–2016, using nationwide registries. Individuals with diabetes and Charcot foot were identified and matched by diabetes type and with similar diabetes duration with individuals with diabetes but not Charcot foot. Logistic regression analyses were used to identify risk factors.

Results

A total of 3397 participants with diabetes mellitus and Charcot foot and 27,662 control participants with diabetes but without Charcot foot were included. HbA_1c, duration of diabetes, micro- and macroalbuminuria, retinopathy and atherosclerosis (general and peripheral) were identified as risk factors for Charcot foot in participants with type 1 diabetes and participants with type 2 diabetes.

Conclusions/interpretation

In the most extensive study on Charcot foot to date, we identified distinctive and common risk factors associated with the development of Charcot foot in individuals with type 1 diabetes and type 2 diabetes.

Graphical Abstract

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来源期刊

Diabetologia 医学-内分泌学与代谢

CiteScore

18.10

自引率

2.40%

发文量

193

审稿时长

1 months

期刊介绍： Diabetologia, the authoritative journal dedicated to diabetes research, holds high visibility through society membership, libraries, and social media. As the official journal of the European Association for the Study of Diabetes, it is ranked in the top quartile of the 2019 JCR Impact Factors in the Endocrinology & Metabolism category. The journal boasts dedicated and expert editorial teams committed to supporting authors throughout the peer review process.