产前接触大麻与后代整个生命过程中神经发育相关基因的 DNA 甲基化改变有关

IF 9.6 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Psychiatry Pub Date : 2024-09-14 DOI:10.1038/s41380-024-02752-w
Alexandra J. Noble, Alex T. Adams, Jack Satsangi, Joseph M. Boden, Amy J. Osborne
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引用次数: 0

摘要

产前接触大麻(PCE)对后代神经发育的潜在影响及其与儿童和青少年大脑发育和认知功能的关系日益受到全球关注。然而,目前还缺乏针对 PCE 分子影响的研究,而这些研究可能有助于澄清 PCE 与神经发育之间的关联。为了填补这一知识空白,我们在此提供了多个时间点的全表观基因组关联研究数据,利用两项纵向研究,即雅芳父母与子女纵向研究(ALSPAC)和基督城健康与发展研究(CHDS),在出生(0 岁)、7 岁和 15-17 岁(ALSPAC)以及约 27 岁(CHDS)时检测 PCE 以及与烟草共同暴露的影响。我们的研究结果表明,后代在 0 岁、7 岁、15-17 岁和 27 岁时的全基因组 DNA 甲基化存在显著差异,这与单独暴露于 PCE 以及与烟草共同暴露有关。重要的是,我们在后代整个发育过程中的不同时间点发现了基因 LZTS2、NPSR1、NT5E、CRIP2、DOCK8、COQ5 和 LRP5 中具有显著差异的 CpG 甲基化位点。值得注意的是,功能通路分析表明,神经发育、神经传递和神经元结构通路中的DNA甲基化差异富集,这在两个队列的所有时间点上都是一致的。鉴于越来越多的流行病学证据表明,PCE 与受暴露后代的不良神经发育结果之间存在联系,这项研究强调了进一步调查 PCE 的必要性,尤其是在更大的队列中进行调查的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course

Prenatal cannabis exposure (PCE) is of increasing concern globally, due to the potential impact on offspring neurodevelopment, and its association with childhood and adolescent brain development and cognitive function. However, there is currently a lack of research addressing the molecular impact of PCE, that may help to clarify the association between PCE and neurodevelopment. To address this knowledge gap, here we present epigenome-wide association study data across multiple time points, examining the effect of PCE and co-exposure with tobacco using two longitudinal studies, the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Christchurch Health and Development Study (CHDS) at birth (0 y), 7 y and 15–17 y (ALSPAC), and ~27 y (CHDS). Our findings reveal genome-wide significant DNA methylation differences in offspring at 0 y, 7 y, 15–17 y, and 27 y associated with PCE alone, and co-exposure with tobacco. Importantly, we identified significantly differentially methylated CpG sites within the genes LZTS2, NPSR1, NT5E, CRIP2, DOCK8, COQ5, and LRP5 that are shared between different time points throughout development in offspring. Notably, functional pathway analysis showed enrichment for differential DNA methylation in neurodevelopment, neurotransmission, and neuronal structure pathways, and this was consistent across all timepoints in both cohorts. Given the increasing volume of epidemiological evidence that suggests a link between PCE and adverse neurodevelopmental outcomes in exposed offspring, this work highlights the need for further investigation into PCE, particularly in larger cohorts.

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来源期刊
Molecular Psychiatry
Molecular Psychiatry 医学-精神病学
CiteScore
20.50
自引率
4.50%
发文量
459
审稿时长
4-8 weeks
期刊介绍: Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.
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