Jiachen Chen, Ahmed A. Y. Ragab, Margaret F. Doyle, Michael L. Alosco, Yuan Fang, Jesse Mez, Claudia L. Satizabal, Wei Qiao Qiu, Joanne M. Murabito, Kathryn L. Lunetta
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Pairwise cross-sectional analysis assessed 68 biomarkers with 13 brain MRI volumes, adjusting for covariates and familial correlations.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Elevated CDCP1, IL6, OPG, and 4E.BP1 were related to smaller total cerebral brain volume (TCBV), whereas higher HGF, IL8, and MMP10 were associated with smaller TCBV, total and frontal white matter volumes. Higher SCF and TWEAK were associated with larger TCBV. In sex-stratified analyses, associations were observed exclusively among males.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>We report several associations between inflammatory biomarkers and brain volumes, highlighting different associations within sex subgroups.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Higher CDCP1, IL6, OPG, and 4E.BP1 levels were associated with smaller TCBV.</li>\n \n <li>Higher levels of HGF, IL8 and MMP10 were associated with smaller TCBV, CWV and FWV.</li>\n \n <li>Higher levels of SCF and TWEAK, were associated with larger TCBV.</li>\n \n <li>Significance diminished in models adjusting for CVD risk factors.</li>\n \n <li>Associations were observed exclusively in males.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 11","pages":"7465-7478"},"PeriodicalIF":11.1000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14147","citationCount":"0","resultStr":"{\"title\":\"Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort\",\"authors\":\"Jiachen Chen, Ahmed A. 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Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort
INTRODUCTION
Brain magnetic resonance imaging (MRI) and inflammatory biomarkers are crucial for investigating preclinical neurocognitive disorders. Current investigations focus on a few inflammatory markers. The study aims to investigate the associations between inflammatory biomarkers and MRI measures and to examine sex differences among the associations in the Framingham Heart Study.
METHODS
Dementia and stroke-free participants underwent OLINK Proteomics profiling and MRI measurements within 5 years. Pairwise cross-sectional analysis assessed 68 biomarkers with 13 brain MRI volumes, adjusting for covariates and familial correlations.
RESULTS
Elevated CDCP1, IL6, OPG, and 4E.BP1 were related to smaller total cerebral brain volume (TCBV), whereas higher HGF, IL8, and MMP10 were associated with smaller TCBV, total and frontal white matter volumes. Higher SCF and TWEAK were associated with larger TCBV. In sex-stratified analyses, associations were observed exclusively among males.
DISCUSSION
We report several associations between inflammatory biomarkers and brain volumes, highlighting different associations within sex subgroups.
Highlights
Higher CDCP1, IL6, OPG, and 4E.BP1 levels were associated with smaller TCBV.
Higher levels of HGF, IL8 and MMP10 were associated with smaller TCBV, CWV and FWV.
Higher levels of SCF and TWEAK, were associated with larger TCBV.
Significance diminished in models adjusting for CVD risk factors.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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