Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Selma J. Padilla Padilla, Nicoletta Murenu, Philipp Stahlhut, Gregor Lang, Zan Lamberger, Jeanette Weigelt, Natascha Schaefer, Jörg Tessmar, Pamela L. Strissel, Torsten Blunk, Silvia Budday, Reiner Strick, Carmen Villmann
{"title":"乳腺肿瘤细胞在类脑细胞外基质中的存活和形态取决于基质成分和机械特性（生物学进展 9/2024）","authors":"Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Selma J. Padilla Padilla, Nicoletta Murenu, Philipp Stahlhut, Gregor Lang, Zan Lamberger, Jeanette Weigelt, Natascha Schaefer, Jörg Tessmar, Pamela L. Strissel, Torsten Blunk, Silvia Budday, Reiner Strick, Carmen Villmann","doi":"10.1002/adbi.202470091","DOIUrl":null,"url":null,"abstract":"<p><b>Breast Tumor Cells</b></p><p>Triple-negative breast cancer (TNBC) is the most invasive type of breast cancer with a high risk of brain metastasis. In article number 2400184, Carmen Villmann and co-workers systematically set up a 3D cellular system to study TNBC in a biomimetic brain surrounding in terms of cell–cell and cell–matrix interactions. 3D disease model for breast tumor cells (green) attached to collagen (red, confocal image) grown in thiolated hyaluronic acid-based hydrogel (background image black). Icons represent MEW PCL scaffolds, PEGAcr crosslinker, different extracellular matrix (ECM) proteins (collagen, fibronectin, laminin). ECM supplementation is the key regulator of cellular morphology behaviour and survival. The original confocal image was modified using an art filter.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":7234,"journal":{"name":"Advanced biology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470091","citationCount":"0","resultStr":"{\"title\":\"Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties (Adv. Biology 9/2024)\",\"authors\":\"Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Selma J. Padilla Padilla, Nicoletta Murenu, Philipp Stahlhut, Gregor Lang, Zan Lamberger, Jeanette Weigelt, Natascha Schaefer, Jörg Tessmar, Pamela L. Strissel, Torsten Blunk, Silvia Budday, Reiner Strick, Carmen Villmann\",\"doi\":\"10.1002/adbi.202470091\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Breast Tumor Cells</b></p><p>Triple-negative breast cancer (TNBC) is the most invasive type of breast cancer with a high risk of brain metastasis. In article number 2400184, Carmen Villmann and co-workers systematically set up a 3D cellular system to study TNBC in a biomimetic brain surrounding in terms of cell–cell and cell–matrix interactions. 3D disease model for breast tumor cells (green) attached to collagen (red, confocal image) grown in thiolated hyaluronic acid-based hydrogel (background image black). Icons represent MEW PCL scaffolds, PEGAcr crosslinker, different extracellular matrix (ECM) proteins (collagen, fibronectin, laminin). ECM supplementation is the key regulator of cellular morphology behaviour and survival. The original confocal image was modified using an art filter.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":7234,\"journal\":{\"name\":\"Advanced biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adbi.202470091\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adbi.202470091\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced biology","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adbi.202470091","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Breast Tumor Cell Survival and Morphology in a Brain-like Extracellular Matrix Depends on Matrix Composition and Mechanical Properties (Adv. Biology 9/2024)
Breast Tumor Cells
Triple-negative breast cancer (TNBC) is the most invasive type of breast cancer with a high risk of brain metastasis. In article number 2400184, Carmen Villmann and co-workers systematically set up a 3D cellular system to study TNBC in a biomimetic brain surrounding in terms of cell–cell and cell–matrix interactions. 3D disease model for breast tumor cells (green) attached to collagen (red, confocal image) grown in thiolated hyaluronic acid-based hydrogel (background image black). Icons represent MEW PCL scaffolds, PEGAcr crosslinker, different extracellular matrix (ECM) proteins (collagen, fibronectin, laminin). ECM supplementation is the key regulator of cellular morphology behaviour and survival. The original confocal image was modified using an art filter.
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