健康和疾病中的胰蛋白酶、糜蛋白酶和弹性蛋白酶

IF 3.4 Q2 PHARMACOLOGY & PHARMACY Future Journal of Pharmaceutical Sciences Pub Date : 2024-09-17 DOI:10.1186/s43094-024-00709-y
Oladoyin Grace Famutimi, Victor Gbolahan Adebiyi, Bukola Grace Akinmolu, Omoniyi Vincent Dada, Isaac Olusanjo Adewale
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引用次数: 0

摘要

背景丝氨酸蛋白酶占人类所有蛋白质的 1%以上。该蛋白家族存在于细胞表面、溶酶体或线粒体等亚细胞器、细胞核和原生质内。摘要正文其中,胰蛋白酶、糜蛋白酶和弹性蛋白酶因其在病理生理过程中的众多功能而引起了人们的极大兴趣。这些酶在实验动物模型和人类中的表达改变与各种病症有关,如发育缺陷、代谢功能障碍、癌症、外周血管疾病和传染病。胰蛋白酶和糜蛋白酶样蛋白酶可激活或灭活多种底物,包括生长因子、受体、粘附分子、血管生成因子和金属蛋白酶。在这些底物中,有一些是癌症进展、转移和严重急性呼吸系统综合症冠状病毒 2(SARS-CoV-2)疾病的关键因素。弹性蛋白降解酶--弹性蛋白酶,在生物体的一生中会缓慢地破坏弹性蛋白。弹性蛋白酶引发的生理过程导致癌症、代谢综合征、肺气肿、动脉粥样硬化和慢性阻塞性肺病等不同疾病的恶化。这些丝氨酸蛋白酶目前被认为是开发新的强效疗法的靶点。简短结论:本文重点介绍了概述这些蛋白酶的生理功能和病理影响的累积知识,以及调控它们的一些活性和靶向治疗应用的拟议策略,并对某些疾病状态进行了验证。这将使我们更加了解它们在某些疾病的病因学中的作用,以及抑制或调节它们所带来的化疗益处。
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Trypsin, chymotrypsin and elastase in health and disease

Background

Serine proteases represent over 1% of all proteins in humans. This family of proteins is found on cell surfaces, subcellular organelles like lysosomes or mitochondria, within the nucleus and the protoplasm.

Main body of the abstract

Among them, trypsin, chymotrypsin and elastase have aroused great interest because of their numerous functions in pathophysiological processes. Altered expression of these enzymes in experimental animal models and humans has been related to various pathologies, like developmental defects, metabolic dysfunctions, cancer, peripheral vascular diseases and infectious diseases. Trypsin and chymotrypsin-like proteases activate, or less oftentimes inactivate, numerous substrates, together with growth factors, receptors, adhesion molecules, angiogenic factors and metalloproteases. Among these substrates, a number of them are key factors in cancer progression, metastasis and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease. Elastin-degrading enzyme- elastase, slowly damages elastin over the lifetime of an organism. The physiological processes triggered by elastase leads to the progression of different conditions such as cancer, metabolic syndrome, pulmonary emphysema, atherosclerosis, and chronic obstructive pulmonary disease. These serine proteases are currently considered to be targets for the development of new potent therapeutics.

Short conclusion

The cumulative knowledge that outlined the physiological functions and pathological implications of these proteases and the proposed strategies to regulate a number of their activities and their targeting for therapeutic application and validation in selected disease states are highlighted. These should enhance our appreciation of their roles in aetiology of some diseases as well as the chemotherapeutic benefits of their inhibition or modulation.

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来源期刊
自引率
0.00%
发文量
44
审稿时长
23 weeks
期刊介绍: Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.
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