Wen-Li Xu, Yu-Han Zhang, Jing-Ru Yuan, Di Jing, Cheng-Yang Tang, Chuan-Bao Zhang, Qiu-Xia Han, Ji-Ya Fu
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Organocatalytic Asymmetric Tandem Reaction of Indene-Based Dienes for the Synthesis of Enantioenriched Spirodihydrofluorenes and Fluorenylamine-ketoximes Containing Axial Elements
An efficient asymmetric tandem reaction of indene-based dienes with isoxazole-5-ones catalyzed by chiral cinchona alkaloid-derived thioureas has been established, constructing a diverse array of novel enantioenriched spirodihydrofluorene compounds bearing isoxazolone moieties. More importantly, the spirodihydrofluorene frameworks can be effortlessly transformed into an atropisomeric fluorene skeleton bearing oxime groups. This work not only addresses the challenges in the construction of enantioenriched spirodihydrofluorene frameworks but also provides a powerful strategy for structurally novel fluorenylamine-ketoximes containing axial elements.
期刊介绍:
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.