使用疫苗的流行性腮腺炎异质性连续年龄结构模型

IF 8.8 3区 医学 Q1 Medicine Infectious Disease Modelling Pub Date : 2024-09-13 DOI:10.1016/j.idm.2024.09.004
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引用次数: 0

摘要

在经典的腮腺炎模型中,一般假定个体是均匀混合的(同质),而忽略了群体的异质性(偏好、活动等)。在建立腮腺炎数学模型时,年龄是捕捉混合模式的关键。本文建立了一个接种疫苗的腮腺炎连续异质性年龄结构模型。年龄结构模型的稳定性是一个难题。本文定义了有疫苗或无疫苗的各种混合模式(隔离、比例和异质混合)的 R0 的明确公式。结果表明,如果 R0 > 1 不需要任何附加条件,则地方性稳态是唯一和局部稳定的。为支持该理论,还给出了一些数值示例。
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A heterogeneous continuous age-structured model of mumps with vaccine

In classical mumps models, individuals are generally assumed to be uniformly mixed (homogeneous), ignoring population heterogeneity (preference, activity, etc.). Age is the key to catching mixed patterns in developing mathematical models for mumps. A continuous heterogeneous age-structured model for mumps with vaccines has been developed in this paper. The stability of age-structured models is a difficult question. An explicit formula of R0 was defined for the various mixing modes (isolation, proportional and heterogeneous mixing) with or without the vaccine. The results show that the endemic steady state is unique and locally stable if R0 > 1 without any additional conditions. A number of numerical examples are given to support the theory.

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来源期刊
Infectious Disease Modelling
Infectious Disease Modelling Mathematics-Applied Mathematics
CiteScore
17.00
自引率
3.40%
发文量
73
审稿时长
17 weeks
期刊介绍: Infectious Disease Modelling is an open access journal that undergoes peer-review. Its main objective is to facilitate research that combines mathematical modelling, retrieval and analysis of infection disease data, and public health decision support. The journal actively encourages original research that improves this interface, as well as review articles that highlight innovative methodologies relevant to data collection, informatics, and policy making in the field of public health.
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