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IF 3.3 3区医学 Q3 IMMUNOLOGY Microbial pathogenesis Pub Date : 2024-09-16 DOI:10.1016/j.micpath.2024.106937

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引用次数: 0

摘要

细菌耐药性的蔓延已成为一个重大的公共卫生问题，导致医疗成本、死亡率和发病率上升。印度丁香和肉桂精油的主要成分丁香酚等植物化学物质因其抗菌潜力而备受关注。因此，本系统综述旨在分析有关丁香酚抗菌潜力的现有文献，涉及其对生物膜、细菌通讯系统（法定量感应 - QS）和相关毒力因子的活性。为此，我们系统地检索了四个数据库，以检索 2010 年至 2023 年间发表的文章。根据资格标准以及通过最低抑菌浓度（MIC）测定、生物膜研究和毒力因子评估进行的抗菌活性评估，共筛选出 14 篇文章。研究结果表明，丁香酚具有抗菌、抗生物膜、抗病毒和抗 QS 的潜力，可用于抗击与慢性、牙科和食源性感染有关的各种细菌菌株，包括耐药菌株，尤其是 ESKAPE 组（肠球菌属、金黄色葡萄球菌、肺炎克雷伯氏菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）和临床分离菌株。此外，丁香酚还能有效靶向参与细菌毒力调节、生物膜和 QS 的关键基因，这一点已得到多种检测方法和研究技术数据的支持。这篇综述表明，丁香酚对生物膜和毒力因子的抗菌活性可能源于它对不同 QS 系统的影响。最后，丁香酚有望成为抗耐药性细菌感染的潜在候选物质，可作为医疗器械和医院表面的抗生物膜剂、食品工业中的牙膏添加剂，还可作为开发新治疗剂的分子，具有抑制细菌毒力、QS 系统和避免细菌耐药性的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Eugenol as a promising antibiofilm and anti-quorum sensing agent: A systematic review

The spread of bacterial resistance has become a significant public health concern, resulting in increased healthcare costs, mortality, and morbidity. Phytochemicals such as Eugenol, the major component of Indian clove and cinnamon essential oils, have attracted attention due to their antimicrobial potential. Thus, this systematic review aims to analyze the existing literature on the antibacterial potential of Eugenol concerning its activity against biofilms, bacterial communication systems (quorum sensing - QS), and associated virulence factors. For this, four databases were systematically searched to retrieve articles published between 2010 and 2023. Fourteen articles were selected based on eligibility criteria and the evaluation of antibacterial activity through minimum inhibitory concentration (MIC) assays, biofilm studies, and assessment of virulence factors. The results revealed that Eugenol has the potential to act as an antimicrobial, antibiofilm, anti-virulence, and anti-QS agent against a variety of bacterial strains associated with chronic, dental, and foodborne infections, including resistant strains, particularly those in the ESKAPE group (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) and clinical isolates. Furthermore, Eugenol effectively targets key genes involved in bacterial virulence regulation, biofilm, and QS, as supported by data from multiple assays and research techniques. This review suggests Eugenol's antibacterial activity against biofilm and virulence factors likely stems from its influence on different QS systems. Finally, Eugenol holds promise as a potential candidate for combating resistant bacterial infections, serving as an anti-biofilm agent in medical devices and hospital surfaces, as well as in the food industry, as a toothpaste additive, and as a molecule for the development of new therapeutic agents with the potential to inhibit bacterial virulence, QS systems and avoiding bacterial resistance.

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来源期刊

Microbial pathogenesis 医学-免疫学

CiteScore

7.40

自引率

2.60%

发文量

472

审稿时长

56 days

期刊介绍： Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)