{"title":"通过选择性分区进行转录调控：基础牢固的弱相互作用","authors":"Megan Palacio, Dylan J. Taatjes","doi":"10.1016/j.molcel.2024.08.029","DOIUrl":null,"url":null,"abstract":"<p>In this issue of <em>Molecular Cell</em>, De La Cruz, Pradhan, Veettil et al.<span><span><sup>1</sup></span></span> examine how selective partitioning of proteins via low-affinity IDR-dependent interactions may help regulate RNA polymerase II (RNA Pol II) function and identify sequence features that drive partitioning in cells.</p>","PeriodicalId":18950,"journal":{"name":"Molecular Cell","volume":"332 1","pages":""},"PeriodicalIF":14.5000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transcription regulation through selective partitioning: Weak interactions with a strong foundation\",\"authors\":\"Megan Palacio, Dylan J. Taatjes\",\"doi\":\"10.1016/j.molcel.2024.08.029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In this issue of <em>Molecular Cell</em>, De La Cruz, Pradhan, Veettil et al.<span><span><sup>1</sup></span></span> examine how selective partitioning of proteins via low-affinity IDR-dependent interactions may help regulate RNA polymerase II (RNA Pol II) function and identify sequence features that drive partitioning in cells.</p>\",\"PeriodicalId\":18950,\"journal\":{\"name\":\"Molecular Cell\",\"volume\":\"332 1\",\"pages\":\"\"},\"PeriodicalIF\":14.5000,\"publicationDate\":\"2024-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Cell\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.molcel.2024.08.029\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.molcel.2024.08.029","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
在本期《分子细胞》（Molecular Cell）杂志上，De La Cruz、Pradhan、Veettil 等人1 研究了蛋白质通过低亲和性 IDR 依赖性相互作用进行选择性分区如何有助于调节 RNA 聚合酶 II（RNA Pol II）的功能，并确定了细胞中驱动分区的序列特征。
Transcription regulation through selective partitioning: Weak interactions with a strong foundation
In this issue of Molecular Cell, De La Cruz, Pradhan, Veettil et al.1 examine how selective partitioning of proteins via low-affinity IDR-dependent interactions may help regulate RNA polymerase II (RNA Pol II) function and identify sequence features that drive partitioning in cells.
期刊介绍：
Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
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