发育协调障碍儿童和非发育协调障碍儿童在线运动控制过程中的皮层活动:横断面功能性近红外光谱研究

IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of NeuroEngineering and Rehabilitation Pub Date : 2024-09-14 DOI:10.1186/s12984-024-01465-z
Quting Huang, Michael K. Yeung, Kenneth N. K. Fong, Chi-Wen Chien
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引用次数: 0

摘要

患有发育协调障碍(DCD)的儿童在线运动控制能力受损。研究人员认为,这种障碍可能是由于在利用内部模型控制过程中出现了缺陷。然而,支持这一观点的神经学证据很少,因为很少有神经影像学研究专门关注涉及在线运动控制的任务。因此,本研究旨在调查患有和未患有 DCD 的儿童在完成在线运动调整任务时大脑皮层血流动力学活动的差异。本研究通过便利取样法招募了 20 名患有 DCD 的儿童(平均年龄:9.88 ± 1.67 岁;性别:14M/6F)和 20 名年龄与性别匹配的典型发育(TD)儿童(平均年龄:9.87 ± 1.59 岁;性别:14M/6F)。参加者在两种条件下(有和没有在线伸手调整)完成了双步伸手任务。使用功能性近红外光谱仪记录了任务过程中十个相关区域的皮层血液动力学活动,包括双侧初级躯体感觉皮层、初级运动皮层、前运动皮层、上顶叶皮层和下顶叶皮层。在分析中,氧合血红蛋白(ΔHbO)浓度的变化被用来描述血液动力学反应。对每个相关区域进行了双向方差分析,以比较不同组别和条件下的血液动力学反应。此外,还进行了血液动力学反应与任务表现之间的皮尔逊 r 相关性分析。结果显示,与对照组相比,患有 DCD 的儿童需要更多的时间来纠正他们的伸手动作(t = 3.948,P < 0.001)。此外,与 TD 儿童相比,DCD 儿童在动作纠正过程中左上顶叶皮层的 ΔHbO 变化明显较低(F = 4.482,P = 0.041)。此外,在左上顶叶皮层中,伸手运动时间的差异与不同条件下的ΔHbO差异之间存在明显的负相关(r = - 0.598,P < 0.001)。本研究的结果表明,考虑到顶叶上皮层的功能,处理实时感觉反馈的缺陷可能与在 DCD 儿童中观察到的在线运动控制受损有关。可以针对这一问题进行干预,以提高他们的在线运动控制能力。
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Cortical activity during online motor control in children with and without developmental coordination disorder: a cross-sectional functional near-infrared spectroscopy study
Children with developmental coordination disorder (DCD) have impaired online motor control. Researchers posit that this impairment could be due to a deficit in utilizing the internal model control process. However, there is little neurological evidence to support this view because few neuroimaging studies have focused specifically on tasks involving online motor control. Therefore, the aim of this study was to investigate the differences in cortical hemodynamic activity during an online movement adjustment task between children with and without DCD. Twenty children with DCD (mean age: 9.88 ± 1.67 years; gender: 14M/6F) and twenty age-and-gender matched children with typical development (TD) (mean age: 9.87 ± 1.59 years; gender: 14M/6F) were recruited via convenience sampling. Participants performed a double-step reaching task under two conditions (with and without online adjustment of reaching). Cortical hemodynamic activity during task in ten regions of interest, including bilateral primary somatosensory cortex, primary motor cortex, premotor cortex, superior parietal cortex, and inferior parietal cortex was recorded using functional near-infrared spectroscopy. In the analyses, change in oxyhemoglobin (ΔHbO) concentration was used to characterize hemodynamic response. Two-way analyses of variance were conducted for each region of interest to compare hemodynamic responses between groups and conditions. Additionally, Pearson’s r correlations between hemodynamic response and task performance were performed. Outcome showed that children with DCD required significantly more time to correct their reaching movements compared to the control group (t = 3.948, P < 0.001). Furthermore, children with DCD have a significantly lower ΔHbO change in the left superior parietal cortex during movement correction, compared to children with TD (F = 4.482, P = 0.041). Additionally, a significant negative correlation (r = − 0.598, P < 0.001) was observed between the difference in movement time of reaching and the difference in ΔHbO between conditions in the left superior parietal cortex. The findings of this study suggest that deficiencies in processing real-time sensory feedback, considering the function of the superior parietal cortex, might be related to the impaired online motor control observed in children with DCD. Interventions could target this issue to enhance their performance in online motor control.
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来源期刊
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation 工程技术-工程:生物医学
CiteScore
9.60
自引率
3.90%
发文量
122
审稿时长
24 months
期刊介绍: Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
期刊最新文献
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