美国成年人血清钙与代谢健康肥胖的关系:一项横断面研究。

IF 4.9 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Annals of medicine Pub Date : 2024-09-18 DOI:10.1080/07853890.2024.2403721
Zhanbin Li,Zhenyu Yao,Qiaoran Liu
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引用次数: 0

摘要

目的血清钙与 MHO(代谢健康型肥胖)和 MUNO(代谢不健康型非肥胖)之间的关系仍不清楚,在初级医疗保健单位中很难区分这两种表型。本研究对这种关系进行了探讨。方法本调查纳入了 2001-2018 年美国国家健康与营养调查(NHANES)中的 28590 名成年人。肥胖表型根据体重指数和是否存在代谢综合征成分进行分类。加权多变量逻辑回归分析用于评估血清钙水平与肥胖表型之间的关联。限制性三次样条分析描述了剂量-反应关系,分层分析探讨了这些关系与社会人口学和生活方式因素之间的关系。结果MHO和MUNO的总患病率分别为2.6%和46.6%。调整协变量后,血清钙与 MHO 呈负相关[OR (95%):0.49 (0.36,0.67),p < 0.001],而与 MUNO 呈正相关[OR (95%):1.48 (1.26,1.84),p < 0.001]。此外,我们还发现血清钙水平与 MHO 和 MUNO 的发病率之间存在非线性关系。分层分析表明,在不同的亚组中,血清钙水平与 MHO 的发生率呈强负相关。除性别外,血钙与分层变量之间不存在明显的交互作用;女性患者的血钙与 MHO 发生率之间的关系更为明显。同时,血清钙水平对所有患者发生 MUNO 的预测能力在不同亚组中是一致的。血钙水平与基于年龄、性别、种族和吸烟状况的分层变量之间存在明显的交互作用;老年(≥ 40 岁)、白人、不吸烟或少吸烟和女性患者的血钙水平与 MHO 或 MUNO 的相关性显著。研究结果表明,血清钙水平可作为一个指标,用于更准确地评估和诊断 MUNO 和 MHO,尤其是腹型肥胖患者。
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Association of serum calcium and metabolically healthy obese in US adults: a cross-sectional study.
OBJECTIVES The relationship between serum calcium and occurrence of MHO (metabolically healthy obesity) and MUNO (metabolically unhealthy non-obesity) remains unclear, and distinguishing these two phenotypes is difficult within primary healthcare units. This study explores that relationship. METHODS This survey included 28590 adults from the National Health and Nutrition Examination Survey (NHANES) 2001-2018. Obesity phenotypes were categorized based on BMI and presence or absence of metabolic syndrome components. Weighted multivariate logistic regression analyses were used to assess the association between serum calcium levels and the obesity phenotype. Restricted cubic spline analysis characterized dose-response relationships, and stratified analyses explored these relationships across sociodemographic and lifestyle factors. RESULTS The overall prevalence of MHO and MUNO were 2.6% and 46.6%, respectively. After adjusting for covariates, serum calcium exhibited a negative association with MHO [OR (95%): 0.49 (0.36,0.67), p < 0.001], while exhibiting a positive association with MUNO [OR (95%): 1.48 (1.26,1.84), p < 0.001]. Additionally, we found a non-linear association between serum calcium levels and the incidences of MHO and MUNO. Stratified analyses demonstrated a strong negative correlation between serum calcium levels and MHO occurrence across various subgroups. There was no significant interaction between calcium and stratified variables except sex; the association between calcium and the occurrence of MHO was remarkable in female patients. Meanwhile, the predictive ability of serum calcium level for the occurrence of MUNO among all patients was consistent across various subgroups. There was a significant interaction between calcium level and stratified variables based on age, sex, race, and smoking status; the association was remarkable in older (≥ 40 years old), white, none or less smoking, and female patients. CONCLUSIONS A significant correlation was identified between serum calcium levels and MHO or MUNO. The findings suggest that serum calcium levels may serve as an indicator for more accurate assessment and diagnosis of MUNO and MHO, especially among individuals with abdominal obesity.
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来源期刊
Annals of medicine
Annals of medicine 医学-医学:内科
CiteScore
4.90
自引率
0.00%
发文量
292
审稿时长
3 months
期刊介绍: Annals of Medicine is one of the world’s leading general medical review journals, boasting an impact factor of 5.435. It presents high-quality topical review articles, commissioned by the Editors and Editorial Committee, as well as original articles. The journal provides the current opinion on recent developments across the major medical specialties, with a particular focus on internal medicine. The peer-reviewed content of the journal keeps readers updated on the latest advances in the understanding of the pathogenesis of diseases, and in how molecular medicine and genetics can be applied in daily clinical practice.
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