非编码基因组内的变异影响人类白细胞抗原基因的遗传和表观遗传调控

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Materials & Interfaces Pub Date : 2024-09-18 DOI:10.3389/fimmu.2024.1422834
Thilona Arumugam, Theolan Adimulam, Anmol Gokul, Veron Ramsuran
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引用次数: 0

摘要

非编码基因组内的变异可能会影响参与免疫控制的重要基因的调控和表达,如人类白细胞抗原(HLA)系统。I 类和 II 类 HLA 分子对 T 淋巴细胞活化所需的肽呈递至关重要。HLA I 类和 II 类基因非编码区的单核苷酸多态性可能会影响转录因子和染色质模型分子的结合,从而影响这些基因的表达。此外,遗传因素和表观遗传因素之间的相互作用也可能影响 HLA 的表达。表观遗传因素,如 DNA 甲基化和非编码 RNA,可在不改变 DNA 序列的情况下调节基因表达。然而,遗传变异可能会促进或允许基因逃避表观遗传因子的调控,从而导致基因表达的改变。HLA 系统是大多数疾病的核心,因此,了解遗传学和表观遗传学对 HLA 调节的作用将对医疗保健产生巨大影响。从这些研究中获得的知识可能会带来新颖且具有成本效益的诊断方法和治疗干预措施。本综述讨论了非编码变异对 HLA 调节的作用。此外,我们还通过评估基于 I 类和 II 类 HLA 基因中 DNA 甲基化和 miRNA 调控位点的多态性的文献,讨论了遗传和表观遗传因素对 HLA 调控的相互作用。我们还深入探讨了 HLA 非编码基因组对疾病的重要性,讨论了整个 HLA 区域的种族特异性差异,并为未来的 HLA 研究提供了指导。
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Variation within the non-coding genome influences genetic and epigenetic regulation of the human leukocyte antigen genes
Variation within the non-coding genome may influence the regulation and expression of important genes involved in immune control such as the human leukocyte antigen (HLA) system. Class I and Class II HLA molecules are essential for peptide presentation which is required for T lymphocyte activation. Single nucleotide polymorphisms within non-coding regions of HLA Class I and Class II genes may influence the expression of these genes by affecting the binding of transcription factors and chromatin modeling molecules. Furthermore, an interplay between genetic and epigenetic factors may also influence HLA expression. Epigenetic factors such as DNA methylation and non-coding RNA, regulate gene expression without changing the DNA sequence. However, genetic variation may promote or allow genes to escape regulation by epigenetic factors, resulting in altered expression. The HLA system is central to most diseases, therefore, understanding the role of genetics and epigenetics on HLA regulation will tremendously impact healthcare. The knowledge gained from these studies may lead to novel and cost-effective diagnostic approaches and therapeutic interventions. This review discusses the role of non-coding variants on HLA regulation. Furthermore, we discuss the interplay between genetic and epigenetic factors on the regulation of HLA by evaluating literature based on polymorphisms within DNA methylation and miRNA regulatory sites within class I and Class II HLA genes. We also provide insight into the importance of the HLA non-coding genome on disease, discuss ethnic-specific differences across the HLA region and provide guidelines for future HLA studies.
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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