Merve Aktan Suzgun, Gulcin Benbir Senel, Derya Karadeniz
{"title":"大肌肉运动对阻塞性睡眠呼吸暂停患者白天过度嗜睡的影响","authors":"Merve Aktan Suzgun, Gulcin Benbir Senel, Derya Karadeniz","doi":"10.1007/s11325-024-03156-4","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Obstructive sleep apnea (OSA) is a heterogeneous disorder requiring personalized diagnostic approaches. Restless sleep and excessive daytime sleepiness (EDS) frequently accompany OSA, and are mainly linked to sleep fragmentation secondary to apneas and/or hypopneas. In this study, we aimed to analyze the characteristics of LMMs in OSA and to evaluate interrelationship between LMMs and EDS.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Untreated-naïve adult OSA patients, with vs. without EDS were prospectively enrolled. Patients with comorbid neurological/psychiatric diagnosis, usage of drugs/substances known to affect sleep and positive airway pressure therapy were excluded. Routine evaluation of video-polysomnography was followed by LMM scoring. LMMs were compared between OSA with vs. without EDS, and correlations of LMMs with ESS scores and macrostructural sleep parameters were analyzed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Sixty patients were included (median age 43.5 [37.0] years, %78.3 men); 17 had EDS with Epworth Sleepiness Scale (ESS) ≥ 10 (28.3%). Total LMM index in total sleep time (TST) was 7.9 [20.6]. Total LMM index in TST (<i>p</i> = 0.048) and N1 (<i>p</i> = 0.020), and arousal-related LMM index in TST (<i>p</i> = 0.050) and N1 (<i>p</i> = 0.026) were higher in OSA with EDS than those without EDS. ESS scores were positively correlated with total (<i>r</i> = 0.332,<i>p</i> = 0.028) and arousal-related (<i>r</i> = 0.338,<i>p</i> = 0.025) LMM indexes in N1, and abnormal respiratory event-related LMM indexes in N1 (<i>r</i> = 0.440,<i>p</i> = 0.003) and N3 (<i>r</i> = 0.293,<i>p</i> = 0.050) after correction for age, sex, body-mass-index and apnea-hypopnea index.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Our study demonstrated that LMMs were more frequent in OSA with EDS than those without EDS. This may have broad implications for the mechanisms of motor restlessness and residual sleepiness in OSA and warrants larger-scale, long-term follow-up studies.</p><h3 data-test=\"abstract-sub-heading\">Clinical trial registration</h3><p>No clinical trial registration due to the observational design of the study.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"75 1","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of large muscle movements on excessive daytime sleepiness in patients with obstructive sleep apnea\",\"authors\":\"Merve Aktan Suzgun, Gulcin Benbir Senel, Derya Karadeniz\",\"doi\":\"10.1007/s11325-024-03156-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Purpose</h3><p>Obstructive sleep apnea (OSA) is a heterogeneous disorder requiring personalized diagnostic approaches. Restless sleep and excessive daytime sleepiness (EDS) frequently accompany OSA, and are mainly linked to sleep fragmentation secondary to apneas and/or hypopneas. In this study, we aimed to analyze the characteristics of LMMs in OSA and to evaluate interrelationship between LMMs and EDS.</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>Untreated-naïve adult OSA patients, with vs. without EDS were prospectively enrolled. Patients with comorbid neurological/psychiatric diagnosis, usage of drugs/substances known to affect sleep and positive airway pressure therapy were excluded. Routine evaluation of video-polysomnography was followed by LMM scoring. LMMs were compared between OSA with vs. without EDS, and correlations of LMMs with ESS scores and macrostructural sleep parameters were analyzed.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>Sixty patients were included (median age 43.5 [37.0] years, %78.3 men); 17 had EDS with Epworth Sleepiness Scale (ESS) ≥ 10 (28.3%). Total LMM index in total sleep time (TST) was 7.9 [20.6]. Total LMM index in TST (<i>p</i> = 0.048) and N1 (<i>p</i> = 0.020), and arousal-related LMM index in TST (<i>p</i> = 0.050) and N1 (<i>p</i> = 0.026) were higher in OSA with EDS than those without EDS. ESS scores were positively correlated with total (<i>r</i> = 0.332,<i>p</i> = 0.028) and arousal-related (<i>r</i> = 0.338,<i>p</i> = 0.025) LMM indexes in N1, and abnormal respiratory event-related LMM indexes in N1 (<i>r</i> = 0.440,<i>p</i> = 0.003) and N3 (<i>r</i> = 0.293,<i>p</i> = 0.050) after correction for age, sex, body-mass-index and apnea-hypopnea index.</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>Our study demonstrated that LMMs were more frequent in OSA with EDS than those without EDS. 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The role of large muscle movements on excessive daytime sleepiness in patients with obstructive sleep apnea
Purpose
Obstructive sleep apnea (OSA) is a heterogeneous disorder requiring personalized diagnostic approaches. Restless sleep and excessive daytime sleepiness (EDS) frequently accompany OSA, and are mainly linked to sleep fragmentation secondary to apneas and/or hypopneas. In this study, we aimed to analyze the characteristics of LMMs in OSA and to evaluate interrelationship between LMMs and EDS.
Methods
Untreated-naïve adult OSA patients, with vs. without EDS were prospectively enrolled. Patients with comorbid neurological/psychiatric diagnosis, usage of drugs/substances known to affect sleep and positive airway pressure therapy were excluded. Routine evaluation of video-polysomnography was followed by LMM scoring. LMMs were compared between OSA with vs. without EDS, and correlations of LMMs with ESS scores and macrostructural sleep parameters were analyzed.
Results
Sixty patients were included (median age 43.5 [37.0] years, %78.3 men); 17 had EDS with Epworth Sleepiness Scale (ESS) ≥ 10 (28.3%). Total LMM index in total sleep time (TST) was 7.9 [20.6]. Total LMM index in TST (p = 0.048) and N1 (p = 0.020), and arousal-related LMM index in TST (p = 0.050) and N1 (p = 0.026) were higher in OSA with EDS than those without EDS. ESS scores were positively correlated with total (r = 0.332,p = 0.028) and arousal-related (r = 0.338,p = 0.025) LMM indexes in N1, and abnormal respiratory event-related LMM indexes in N1 (r = 0.440,p = 0.003) and N3 (r = 0.293,p = 0.050) after correction for age, sex, body-mass-index and apnea-hypopnea index.
Conclusion
Our study demonstrated that LMMs were more frequent in OSA with EDS than those without EDS. This may have broad implications for the mechanisms of motor restlessness and residual sleepiness in OSA and warrants larger-scale, long-term follow-up studies.
Clinical trial registration
No clinical trial registration due to the observational design of the study.
期刊介绍：
The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep.
Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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