Yufu Liu, Hongwei Zhang, Tianyan Chen, Chang Xu, Xingfu Bao
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引用次数: 0
摘要
金属有机框架(MOFs)是一类新型智能生物材料,具有广阔的应用前景,在生物医学领域得到广泛应用。目前的研究表明,骨关节炎(OA)的治疗策略主要局限于改善症状、减轻疼痛和炎症。因此,将 MOFs 引入 OA 的治疗有望带来显著的益处。这是因为 MOFs 不仅具有固有的生物活性,还可作为载体促进药物的可控递送,延长治疗 OA 的持续时间。本文综述了近期探索将 MOFs 作为药物或载体用于治疗 OA 的潜在用途的研究,同时还探讨了 MOFs 在组织工程学治疗 OA 方面的进展。预计这些研究不仅能加深人们对 MOFs 的理解,还能为利用 MOFs 治疗 OA 提供有力证据。
Metal-organic frameworks (MOFs) and their derivatives as emerging biomaterials for the treatment of osteoarthritis
As a novel class of smart biomaterials with promising potentials, metal-organic frameworks (MOFs) are widely utilized in the field of biomedicine. Current researches indicate that the therapeutic strategies for osteoarthritis (OA) are highly limited to achieving symptom improvement and reducing both pain and inflammation. Together, the introduction of MOFs into the treatment of OA holds the potential to offer significant benefits. This is because MOFs not only have intrinsic biological activities, but also act as carriers to facilitate controlled drug delivery and prolong the duration in the management of OA. This paper presents a review of the recent studies that have explored the potential usage of MOFs as drugs or carriers in the treatment of OA, which also examines the progress of MOFs in tissue engineering for the treatment of OA. These studies are anticipated to not only enhance the comprehension of MOFs but also provide strong evidence in favor of their utilization in the treatment of OA.
期刊介绍:
Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.