闭合硼酸阴离子脒衍生物 [B10H10]2- 和 [B12H12]2- 的三乙基铵盐的合成及其细胞毒性研究

IF 1.8 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Russian Journal of Inorganic Chemistry Pub Date : 2024-09-15 DOI:10.1134/s0036023624601892

M. N. Ryabchikova, A. V. Nelyubin, I. N. Klyukin, N. Yu. Karpechenko, A. P. Zhdanov, K. Yu. Zhizhin, N. T. Kuznetsov

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引用次数: 0

摘要

摘要获得了一系列以三乙基铵为阳离子的癸羧酸盐和十二羧酸盐脒衍生物。这些化合物的结构是通过多核核磁共振波谱和 ESI 质谱法确定的。用 MTT 法研究了所有化合物对四种细胞系的细胞毒性。结果表明，阳离子的性质并不影响所讨论的取代封闭硼酸盐的细胞毒性。

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Synthesis of Triethylammonium Salts of Amidine Derivatives of closo-Borate Anions [B10H10]2– and [B12H12]2– and Study of Their Cytotoxic Properties

Abstract

A series of amidine derivatives of the closo-decaborate and closo-dodecaborate anions with triethylammonium cations were obtained. The structures of the compounds was determined by multinuclear NMR spectroscopy and ESI-mass spectrometry. Cytotoxicity of all compounds obtained was investigated by MTT method on four cell lines. It was shown that the nature of the cation does not affect the cytotoxicity of the substituted closo-borates discussed.

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来源期刊

Russian Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

3.10

自引率

38.10%

发文量

237

审稿时长

3 months

期刊介绍： Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.