山奈酚对TRPC5的药理调控可通过抑制钙离子参与形成丝状体来减轻胃肠癌的转移

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-09-16 DOI:10.7150/ijbs.87829
Suyun Yu, Rui Deng, Wei Wang, Defang Zou, Liang He, Zhonghong Wei, Yanhong Pan, Xiaoman Li, Yuanyuan Wu, Aiyun Wang, Wenxing Chen, Yang Zhao, Yin Lu
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引用次数: 0

摘要

热感觉受体瞬时受体电位通道 5(TRPC5)是一种非选择性钙离子(Ca2+)渗透离子通道,它与癌症的发生和发展有关。然而,它在胃肠癌中的具体作用仍不清楚。本研究表明,TRPC5 在胃肠道肿瘤中显著过表达,并与患者的预后成反比。TRPC5 过表达会引发细胞内 Ca2+ 水平([Ca2+]i)大幅升高,从而推动肌动蛋白细胞骨架重组,促进丝状体形成。此外,山奈酚(一种源自传统中药的化合物)被确定为 TRPC5 抑制剂,可有效抑制其活性,从而阻碍胃肠癌转移。这些发现强调了TRPC5作为转移抑制治疗靶点的潜力,山奈酚是一种很有前景的天然抑制剂,可优化用于临床预防癌症转移。
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Pharmacological manipulation of TRPC5 by kaempferol attenuates metastasis of gastrointestinal cancer via inhibiting calcium involved in the formation of filopodia
The thermo-sensory receptor, transient receptor potential channel 5 (TRPC5), a non-selective calcium ion (Ca2+)-permeable ion channel, has been implicated in cancer initiation and progression. However, its specific role in gastrointestinal cancer remains unclear. This study demonstrates that TRPC5 is significantly overexpressed in gastrointestinal tumors and is inversely associated with patient prognosis. TRPC5 overexpression triggers a substantial elevation in intracellular Ca2+ levels ([Ca2+]i), driving actin cytoskeleton reorganization and facilitating filopodia formation. Furthermore, kaempferol, a compound sourced from traditional Chinese medicine, is identified as a TRPC5 inhibitor that effectively suppresses its activity, thereby impeding gastrointestinal cancer metastasis. These findings underscore the potential of TRPC5 as a therapeutic target for metastasis inhibition, with kaempferol emerging as a promising natural inhibitor that could be optimized for clinical use in preventing cancer metastasis.
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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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