有效治疗肾移植受者的集合管癌:病例报告。

IF 2.5 4区 医学 Q3 ONCOLOGY Oncology Letters Pub Date : 2024-09-03 DOI:10.3892/ol.2024.14661
Tabata Carolina Faria Nascimento de Assis,Liane Rapatoni,Flavio Nogueira Segato,Barbhara Thais Maciel Pontes,Valdair Francisco Muglia,Miguel Moyses Neto,Elen Almeida Romao
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摘要

集合管癌(CDC)是一种死亡率很高的罕见疾病。本研究描述了一例患有转移性同种异体 CDC 的肾移植受者,其治疗取得了成功。患者在接受血液透析治疗的同时,接受了肾切除术、吉西他滨和顺铂化疗,随访 6 年后病情仍在缓解。目前缺乏有关 CDC 治疗和临床管理的信息,但吉西他滨和顺铂联合疗法仍是一线疗法。本病例面临的挑战是将化疗疗程与透析治疗相结合,以保持肿瘤治疗的有效性、耐受性和安全性。在本病例报告中,吉西他滨和顺铂联合化疗成功治疗了一名终末期肾病患者的转移性肾异位移植 CDC,副作用小,且在治疗结束 6 年后没有复发。
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Effective treatment of collecting duct carcinoma in a recipient of a kidney transplant: A case report.
Collecting duct carcinoma (CDC) is a rare disease associated with a high mortality rate. The present study describes the case of a recipient of a kidney transplant with metastatic allograft CDC whose treatment was successful. The patient underwent nephrectomy, and chemotherapy with gemcitabine and cisplatin, while undergoing haemodialysis treatment and remained in remission after 6 years of follow-up. There is a lack of information about the treatment and clinical management of CDC; however, the combination of gemcitabine and cisplatin remains as first-line therapy. The challenge of this case was integrating chemotherapy sessions with dialysis therapy to maintain the effectiveness, tolerability and safety of the oncological treatment. In the present case report, the success of chemotherapy with gemcitabine and cisplatin was demonstrated in a metastatic renal allograft CDC in a patient with end-stage renal disease, with few side effects and no recurrence of the disease 6 years after the end of treatment.
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来源期刊
Oncology Letters
Oncology Letters ONCOLOGY-
CiteScore
5.70
自引率
0.00%
发文量
412
审稿时长
2.0 months
期刊介绍: Oncology Letters is a monthly, peer-reviewed journal, available in print and online, that focuses on all aspects of clinical oncology, as well as in vitro and in vivo experimental model systems relevant to the mechanisms of disease. The principal aim of Oncology Letters is to provide the prompt publication of original studies of high quality that pertain to clinical oncology, chemotherapy, oncogenes, carcinogenesis, metastasis, epidemiology and viral oncology in the form of original research, reviews and case reports.
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