N. E. Kuz’mina, S. V. Moiseev, E. Yu. Severinova, V. M. Shchukin, N. D. Bunyatyan
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引用次数: 0
摘要
通过重量分析和核磁共振方法[PMR、13C NMR、扩散有序核磁共振光谱(DOSY)]对冷冻前后(分别为样品 I 和 II)的肠凝胶结构进行了比较分析,以了解冷冻对肠凝胶吸附能力产生负面影响的原因。PMR 和 13C NMR 方法表明,样品 I 和 II 中的甲基硅氧烷分子具有等效磁性。用 DOSY 方法估算了样品 I 和 II 的分子质量,样品 I 的分子质量对应于甲基硅酸的环状二聚体(MM 152 Da),样品 II 的分子质量对应于甲基硅酸的线性二聚体(MM 170 Da)。据推测,由于硅氧烷键的断裂,构象刚性环状二聚体结构在肠凝胶冻结时被破坏。由于结构的破坏和疏水性的改变,肠溶凝胶的吸附能力下降。热重分析表明,水没有参与与肠凝胶的氢键作用。
Study of Changes in Enterosgel Structure in Case of Violation of Drug Storage Conditions
The structure of enterosgel before and after freezing (samples I and II, respectively) was comparatively analyzed by gravimetric analysis and NMR methods [PMR, 13C NMR, diffusion-ordered NMR spectroscopy (DOSY)] to understand the reason for the negative effect of freezing on the adsorption capacity of enterosgel. The methylsiloxane moieties in samples I and II were shown to be magnetically equivalent by PMR and 13C NMR methods. The molecular masses of samples I and II were estimated by the DOSY method and corresponded to the cyclic dimer of methylsilicic acid (MM 152 Da) for sample I and the linear dimer of methylsilicic acid (MM 170 Da) for sample II. It was hypothesized that the conformationally rigid cyclic dimer structure was destroyed upon freezing of enterosgel due to rupture of a siloxane bond. The adsorption capacity of enterosgel deteriorated because of the structure disruption and hydrophobicity change. Thermogravimetric analysis revealed that water did not participate in hydrogen bonding with enterosgel.
期刊介绍:
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.