热蛋白沉积途径中的泛素化:败血症的潜在治疗靶点

IF 9.3 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine & Growth Factor Reviews Pub Date : 2024-09-06 DOI:10.1016/j.cytogfr.2024.09.001
Yan Liao,Wangzheqi Zhang,Miao Zhou,Chenglong Zhu,Zui Zou
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引用次数: 0

摘要

败血症仍然是一项重大的临床挑战,每年造成无数人死亡,是全球健康的主要负担。脓毒症是一种独特的程序性细胞死亡,其特点是细胞裂解和释放炎症介质,是脓毒症、脓毒性休克和器官功能障碍发病和进展的关键因素。泛素化是影响蛋白质命运的一种关键的翻译后修饰,已成为治疗包括败血症在内的各种炎症的一个有前途的靶点。本综述整合了目前有关脓毒症、热毒血症和泛素系统的知识,重点关注脓毒症期间激活的热毒血症通路中泛素化的分子机制。本综述通过探讨泛素化调节如何调控热蛋白沉积及其相关的炎症信号通路,为脓毒症的潜在治疗策略提供了见解,并强调了进一步研究这些复杂分子网络的必要性。
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Ubiquitination in pyroptosis pathway: A potential therapeutic target for sepsis.
Sepsis remains a significant clinical challenge, causing numerous deaths annually and representing a major global health burden. Pyroptosis, a unique form of programmed cell death characterized by cell lysis and the release of inflammatory mediators, is a crucial factor in the pathogenesis and progression of sepsis, septic shock, and organ dysfunction. Ubiquitination, a key post-translational modification influencing protein fate, has emerged as a promising target for managing various inflammatory conditions, including sepsis. This review integrates the current knowledge on sepsis, pyroptosis, and the ubiquitin system, focusing on the molecular mechanisms of ubiquitination within pyroptotic pathways activated during sepsis. By exploring how modulating ubiquitination can regulate pyroptosis and its associated inflammatory signaling pathways, this review provides insights into potential therapeutic strategies for sepsis, highlighting the need for further research into these complex molecular networks.
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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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