血清可溶性白细胞介素-2 受体α可预测免疫球蛋白 A 肾病的肾小管间质炎症细胞浸润和短期病情进展

IF 3.3 4区 医学 Q3 IMMUNOLOGY Immunologic Research Pub Date : 2024-09-14 DOI:10.1007/s12026-024-09533-1
Chenqi Xu, Kunming Pan, Jie Li, Yang Li, Shi Jin, Yiqin Shi, Jie Teng, Xiaoqiang Ding, Xialian Xu, Hong Liu
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引用次数: 0

摘要

本研究旨在探讨血清可溶性白细胞介素-2受体α(sIL-2Rα)水平与免疫球蛋白A肾病(IgAN)组织学特征之间的关系,并评估其对疾病进展和缓解状态的预测价值。IgAN患者均为回顾性纳入。对李氏分类法、牛津分类法和组织学评分进行了评估。在6个月的随访中收集了患者的估计滤过率(eGFR)和蛋白尿缓解状态。采用逻辑回归法确定风险因素和预测值。采用接收者操作特征曲线(ROC)确定结果的预测值。本研究共纳入 172 名受试者。与非轻度组相比,中重度肾小管间质炎症细胞浸润组患者的血清 sIL-2Rα 水平明显升高。血清 sIL-2Rα 水平与浸润评分呈正相关。血清 sIL-2Rα 是中度至重度炎症细胞浸润的独立危险因素[sIL-2Rα:OR 1.29 (1.015-1.640, p = 0.038)]。当 sIL-2Rα 与 eGFR < 60 mL/(min-1.73 m2)、24 小时蛋白尿排泄量 > 1.0 g 和血红蛋白相结合时,sIL-2Rα 对中重度炎症细胞浸润的预测价值的 ROC 曲线分析表明曲线下面积为 0.859 (0.801-0.918, p = 0.000)。它显示出良好的灵敏度(71.6%)和特异性(87.6%)。此外,肾活检时的 sIL-2Rα 水平是肾活检后 6 个月肾功能丧失的有力预测因素[OR 4.161 (1.013-17.088, p = 0.048)]。高血清 sIL-2Rα 与 IgAN 严重的炎症细胞浸润显著相关,对疾病预后有很强的预测价值。血清sIL-2Rα可能是评估IgAN组织学损伤程度和疾病预后的一种有用的非侵入性生物标志物。
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Serum soluble interleukin-2 receptor alpha may predict tubulointerstitial inflammatory cell infiltration and short-term disease progression in immunoglobin A nephropathy

This study aims to explore the relationship between serum soluble interleukin-2 receptor alpha (sIL-2Rα) levels and histologic features in immunoglobin A nephropathy (IgAN), and evaluate its predicting values on disease progression and remission status. IgAN patients were included retrospectively. Lee classification, Oxford classification and histological scoring were evaluated. Patients’ estimated filtration rate (eGFR) and proteinuria remission status were collected during 6-month follow-up. Logistic regression was used to determine the risk factors and predicting value. Receiver operating characteristic (ROC) curve were used to determine the predicting value for outcome. One hundred seventy-two subjects were included in this study. Individuals in moderate-to-severe tubulointerstitial inflammatory cell infiltration group manifested with significantly elevated serum sIL-2Rα levels than those in non-to-mild group. Serum sIL-2Rα levels were positively correlated with infiltration scores. Serum sIL-2Rα was an independent risk factor for moderate-to-severe inflammatory cell infiltration [sIL-2Rα: OR 1.29 (1.015–1.640, p = 0.038)]. ROC curve analysis regarding predictive value for moderate-to-severe inflammatory cell infiltration of sIL-2Rα suggested area under curve was 0.859 (0.801–0.918, p = 0.000) when sIL-2Rα combined with eGFR < 60 mL/(min·1.73 m2), 24-h proteinuria excretion > 1.0 g, and hemoglobin. It showed good sensitivity (71.6%) and specificity (87.6%). Additionally, sIL-2Rα levels at kidney biopsy were strong predictive factor for kidney function loss 6 months after kidney biopsy [OR 4.161 (1.013–17.088, p = 0.048)]. High serum sIL-2Rα was significantly associated with serious inflammatory cell infiltration in IgAN, and it showed strong predictive value for disease prognosis. Serum sIL-2Rα could be a useful noninvasive biomarker to evaluate the extent of histological injury and disease prognosis in IgAN.

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来源期刊
Immunologic Research
Immunologic Research 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.
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