膳食中补充维生素 B3 可通过髓系细胞中偏向 GPR109A 的信号传导诱导肝癌抗肿瘤免疫力

IF 11.7 1区 医学 Q1 CELL BIOLOGY Cell Reports Medicine Pub Date : 2024-09-17 DOI:10.1016/j.xcrm.2024.101718
Yang Yang, Tianduo Pei, Xiaolin Hu, Yu Lu, Yanqiu Huang, Tingya Wan, Chaobao Liu, Fengqian Chen, Bao Guo, Yuemei Hong, Qian Ba, Xiaoguang Li, Hui Wang
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引用次数: 0

摘要

膳食营养素对肿瘤免疫的影响仍是一个持续研究的领域,尤其是维生素的特定作用及其机制。在这里,我们证明了维生素 B3(VB3)通过偏向髓系细胞的 GPR109A 轴诱导肝癌抗肿瘤免疫。营养流行病学研究表明,摄入更多的 VB3 可降低肝癌风险。在多种小鼠模型中,补充 VB3 可缓解由肿瘤浸润髓系细胞介导的免疫抑制性肿瘤微环境(TME),从而以 CD8+ T 细胞依赖的方式增强免疫疗法或靶向疗法的疗效,从而显示出抗肿瘤功效。从机制上讲,TME 会诱导髓系细胞异常激活 GPR109A/核因子κB(NF-κB),从而形成免疫抑制性 TME。相反,VB3 可激活β-阿restin 介导的 GPR109A 降解和 NF-κB 抑制,从而抑制骨髓细胞的免疫抑制性极化,进而激活 CD8+ T 细胞的细胞毒性功能。总之,这些结果拓展了人们对维生素如何调节TME的认识,表明膳食中补充VB3可作为肝癌的辅助治疗手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell

The impact of dietary nutrients on tumor immunity remains an area of ongoing investigation, particularly regarding the specific role of vitamins and their mechanism. Here, we demonstrate that vitamin B3 (VB3) induces antitumor immunity against liver cancer through biased GPR109A axis in myeloid cell. Nutritional epidemiology studies suggest that higher VB3 intake reduces liver cancer risk. VB3 supplementation demonstrates antitumor efficacy in multiple mouse models through alleviating the immunosuppressive tumor microenvironment (TME) mediated by tumor-infiltrating myeloid cell, thereby augmenting effectiveness of immunotherapy or targeted therapy in a CD8+ T cell-dependent manner. Mechanically, the TME induces aberrant GPR109A/nuclear factor κB (NF-κB) activation in myeloid cell to shape the immunosuppressive TME. In contrast, VB3 activates β-Arrestin-mediated GPR109A degradation and NF-κB inhibition to suppress the immunosuppressive polarization of myeloid cell, thereby activating the cytotoxic function of CD8+ T cell. Overall, these results expand the understanding of how vitamins regulate the TME, suggesting that dietary VB3 supplementation is an adjunctive treatment for liver cancer.

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来源期刊
Cell Reports Medicine
Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
15.00
自引率
1.40%
发文量
231
审稿时长
40 days
期刊介绍: Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.
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