Amit H. Pakhurde, D. V. P. Kishore, Sandeep A. Kotharkar
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Identification, Synthesis, and Characterization of Process Related Impurities in the Synthesis of Boc-L-Lys(Boc)-OSu
Protected lysine esters (Boc-L-Lys(Boc)-OSu) an intermediate of high repute in the peptide synthesis and diverse chemical synthetic applications, was the subject of synthetic process development studies, unveiling process-related impurities. These impurities were synthesized, characterized, and identified by different analytical tools, with their retention times verified by HPLC co-injection with commercial products. Detailed discussions ensued on the potential formation pathways and synthetic strategies of these process-related impurities.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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