Joo-Hyun Jeon, Han-Joo Lee, Jin-Hee Kim, Mohammed B. Hawsawi, Hitesh B. Jalani, Jin-Hyun Jeong
{"title":"2-氯-3-(4,6-二芳基-1,3,5-三嗪-2-基)喹啉的芳基化反应：通过铃木-宫浦反应正式合成 3-(4,6-二芳基-1,3,5-三嗪-2-基)-2-取代的喹啉类化合物","authors":"Joo-Hyun Jeon, Han-Joo Lee, Jin-Hee Kim, Mohammed B. Hawsawi, Hitesh B. Jalani, Jin-Hyun Jeong","doi":"10.1002/jhet.4909","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>We have described herein a simple and formal two-step synthesis of 3-(4,6-diaryl-1,3,5-triazin-2-yl)-2-aryl quinolines from 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines and boronic acids under the Suzuki–Miyaura conditions. This protocol provides the C-2 arylation of 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines under the mild reaction conditions. These newly formed chemo-types may be useful in drug discovery programs or in material chemistry.</p>\n </div>","PeriodicalId":194,"journal":{"name":"Journal of Heterocyclic Chemistry","volume":"61 11","pages":"1795-1800"},"PeriodicalIF":2.0000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Arylation of 2-Chloro-3-(4,6-Diaryl-1,3,5-Triazin-2-yl) Quinolines: Formal Synthesis of 3-(4,6-Diaryl-1,3,5-Triazin-2-yl)-2-Substituted Quinolines by Suzuki–Miyaura Reaction\",\"authors\":\"Joo-Hyun Jeon, Han-Joo Lee, Jin-Hee Kim, Mohammed B. Hawsawi, Hitesh B. Jalani, Jin-Hyun Jeong\",\"doi\":\"10.1002/jhet.4909\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>We have described herein a simple and formal two-step synthesis of 3-(4,6-diaryl-1,3,5-triazin-2-yl)-2-aryl quinolines from 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines and boronic acids under the Suzuki–Miyaura conditions. This protocol provides the C-2 arylation of 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines under the mild reaction conditions. These newly formed chemo-types may be useful in drug discovery programs or in material chemistry.</p>\\n </div>\",\"PeriodicalId\":194,\"journal\":{\"name\":\"Journal of Heterocyclic Chemistry\",\"volume\":\"61 11\",\"pages\":\"1795-1800\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Heterocyclic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jhet.4909\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Heterocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jhet.4909","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Arylation of 2-Chloro-3-(4,6-Diaryl-1,3,5-Triazin-2-yl) Quinolines: Formal Synthesis of 3-(4,6-Diaryl-1,3,5-Triazin-2-yl)-2-Substituted Quinolines by Suzuki–Miyaura Reaction
We have described herein a simple and formal two-step synthesis of 3-(4,6-diaryl-1,3,5-triazin-2-yl)-2-aryl quinolines from 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines and boronic acids under the Suzuki–Miyaura conditions. This protocol provides the C-2 arylation of 2-chloro-3-(4,6-diaryl-1,3,5-triazin-2-yl) quinolines under the mild reaction conditions. These newly formed chemo-types may be useful in drug discovery programs or in material chemistry.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
