哥伦比亚系统性红斑狼疮患者队列中的认知障碍:横断面研究

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-09-17 DOI:10.1177/09612033241273082
Yimy F Medina, Manuela R Rivera, Liliana K Duarte, Carlos M Rodriguez-Plata, Emmanuel R De León, Sonia C Rodríguez Martínez
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引用次数: 0

摘要

背景认知缺陷是与系统性红斑狼疮相关的神经精神综合征。方法和患者这项描述性横断面研究纳入了系统性红斑狼疮患者,通过使用蒙特利尔认知评估(MoCA测试)进行筛查测试来探讨认知障碍的存在,并使用美国风湿病学会推荐的特定神经心理学测试进行诊断确认。结果 大多数患者为女性,中位年龄为 37 岁(IQR,28.0 - 46.7)。大多数患者受过高等教育或技术教育。59名患者(62.9%)的MoCA测试结果≥26分,属于正常;35名患者(37.1%)的MoCA测试结果为<26分,属于异常。31 名(33.0%)MoCA 测试结果异常的患者接受了综合神经心理测试。41名患者(48.8%)患有某种程度的抑郁症。生活质量损失的中位数为 21.03%(IQR 10.2 - 40.3)。19名患者(20%)存在一定程度的认知缺陷,15名患者(占样本总数的15.95%)存在认知障碍,4名患者(占样本总数的4.25%)认知能力下降。在利用接受特定测试的患者数据进行的逻辑回归分析中,发现与认知退化相关的变量与生活质量下降有关,调整后的几率比为 1.05 (CI 1.01-0.09)。结论 在这项研究中,16% 的患者接受了完整的神经心理测试评估,37% 的患者接受了 MoCA 筛查测试。我们的研究结果表明,在对系统性红斑狼疮患者进行咨询时,实施评估认知缺陷、抑郁和生活质量的策略,并提高为狼疮患者提供护理的医疗人员对这些问题的存在及其影响的认识,是至关重要的。
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Cognitive impairment in a Colombian cohort of patients with systemic lupus erythematosus: A cross-sectional study
ContextCognitive deficits are neuropsychiatric syndromes associated with systemic lupus erythematosus. In our context, there are no data on the frequency of cognitive deficit as a manifestation of neuropsychiatric SLE or the associated conditions.ObjectiveTo define determinants of cognitive deficit in a cohort of Colombian patients with SLE attending a third-level hospital.Methods and PatientsThis descriptive cross-sectional study included patients with SLE, explored the presence of cognitive impairment through screening testing using the Montreal Cognitive Assessment (MoCA test), and diagnostic confirmation with a specific neuropsychological test battery recommended by the American College of Rheumatology. Quality of life was assessed using the LupusCol questionnaire and depression using the Beck Depression Inventory.ResultsMost patients were women, with a median age of 37 years (IQR, 28.0 - 46.7). Most patients had a level of higher education or technical education. Fifty-nine (62.9%) patients presented with a normal MoCA test result ≥26 points, and 35 (37.1%) patients with a score <26 points that were considered abnormal. The comprehensive neuropsychological test battery was applied to 31 patients (33.0%) with an abnormal MoCA test. Forty-one patients (48.8%) had some degree of depression. The median loss of quality of life was 21.03% (IQR 10.2 - 40.3). 19 patients (20%) presented some degree of cognitive deficit, 15 (15.95% of the total sample) had cognitive impairment, and 4 (4.25%) had cognitive decline. In a logistic regression analysis using data from patients undergoing specific tests, variables related to cognitive deterioration were found to be associated with a lower quality of life, showing an adjusted odds ratio of 1.05 (CI 1.01-0.09). No association was demonstrated with SLEDAI, prednisolone use, cyclophosphamide use, and the presence of depression.ConclusionIn this study, it was found in 16% of patients evaluated with the complete neuropsychological test battery and in 37% with the MoCA screening test. Our results suggest that it is crucial to implement strategies to assess cognitive deficit, depression, and quality of life in the consultation of patients with SLE and to raise awareness among health providers who care for patients with lupus about their presence and impact.
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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