评估小儿多发性硬化症的中央静脉征和顺磁性边缘病变

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2024-09-18 DOI:10.1002/acn3.52208

Monica Margoni, Paolo Preziosa, Elisabetta Pagani, Loredana Storelli, Mor Gueye, Lucia Moiola, Massimo Filippi, Maria A. Rocca

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摘要

有人建议对显示中央静脉征（CVS）的白质病变（WMLs）和顺磁性边缘病变（PRLs）进行评估，以加强成人多发性硬化症（MS）的诊断工作。我们的目的是评估 22 名儿童多发性硬化症患者是否符合不同的 CVS 标准以及 PRLs 的附加价值。11名患者（50%）符合40%规则阈值。19名患者（86%）有≥3个CVS+ WML或≥1个PRL，而17名患者（77%）有≥6个CVS+ WML或≥1个PRL。在≥6个CVS+ WMLs的患者中合并评估≥1个PRL，这种基于CVS的简化方法可能会改善儿童患者的MS诊断。

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Assessment of central vein sign and paramagnetic rim lesions in pediatric multiple sclerosis

The evaluation of white matter lesions (WMLs) showing the central vein sign (CVS) and paramagnetic rim lesions (PRLs) has been suggested to enhance the diagnostic work-up of adult multiple sclerosis (MS). We aimed to evaluate the fulfillment of different CVS criteria and the added value of PRLs in 22 pediatric MS patients. Eleven patients (50%) fulfilled the 40%-rule threshold. Nineteen (86%) patients had ≥3 CVS+ WMLs or ≥1 PRL, whereas 17 (77%) had ≥6 CVS+ WMLs or ≥1 PRL. A simplified CVS-based approach, with the combined evaluation of ≥1 PRL in patients with ≥6 CVS+ WMLs, may improve MS diagnosis in pediatric patients.

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.